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EC number: 204-706-1 | CAS number: 124-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro study
In an test performed according to the OECD guidelines #471 and GLP (Dawkes, 1997), which included treatments at concentrations up to 10000 µg/plate, methanesulfonyl chloride (purity 99.8%) was assayed for mutation in five histidine-requiring strains (TA98, TA100, TA1535, TA1537 and TA102) of Salmonella typhimurium, both in the absence and in the presence of metabolic activation by an Aroclor 1254-induced rat liver post-mitochondrial fraction (S-9). Methanesulfonyl chloride induced mutagenic activity on TA 1535 and exhibited evidence of weak mutagenic activity in TA 100 strains, both with and without metabolic activation.
In an test performed according to the OECD guidelines #471 and GLP (Dawkes, 1998), which included treatments at concentrations up to 10000 µg/plate, methanesulfonyl chloride (purity 99.8%) was assayed for mutation in two histidine-requiring strains (TA100 and TA1535) ofSalmonella typhimurium, both in the absence and in the presence of metabolic activation by an Aroclor 1254-induced rat liver post-mitochondrial fraction (S-9). Methane sulfonyl chloride induced mutagenic activity on TA 1535, both with and without metabolic activation.
Methanesulfonyl chloride (purity 99.85%) was tested in an in vitro cytogenetics assay performed according to the OECD guidelin #473 and GLP (Marshall, 1997). Treatments of duplicate human lymphocyte cultures were performed both in the absence and presence of metabolic activation by a rat liver post-mitochondrial fraction (S-9) from Aroclor 1254 induced animals. The test article was dissolved in acetone and the highest dose level used, 1150 µg/mL, was equivalent to a concentration of 10 mM. Methanesulfonyl chloride induced chromosome aberrations in cultured human peripheral blood lymphocytes. The effect was seen following treatment in both the absence and presence of S-9.
In vivo study
The potential of methanesulfonyl chloride (purity 99.9%) to induce structural or numerical damage in bone marrow cells of mice was evaluated a study performed according to the OECD guideline #474 and GLP (Haddouk, 2003).
Three groups of five male and five female mice were given intraperitoneal administrations (10 ml/kg) of methanesulfonyl chloride at dose-levels of 0 (paraffin oil), 7.5,15 and 30 mg/kg/day, over a 2-day period. One group of five males and five females received the positive control test item (cyclophosphamide) once by oral route at the dose-level of 50 mg/kg.
Animal were sacrificed 24 hours after the last administration, and bone marrow smears examined for the presence of micronuclei in 2000 polychromatic erythrocytes per mouse and for the ratio PCE/NCE.
For both males and females, the mean values of MPE as well as the PE/NE ratio in the groups treated with the test item, were equivalent to those of the vehicle group. Methanesulfonyl chloride was concluded to be negative in the mouse micronucleus assay.Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Not classified for germ cells mutation.
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