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EC number: 206-354-4 | CAS number: 330-54-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Time course concentrations were determined from duplicate sampling at any observation time. Samples were taken at the beginning of the test and after 6, 24, 48, 75, 96 and 120 hours.
- Buffers:
- - pH: 4
- Type and final molarity of buffer: 0.05M citrate buffer
- pH: 7
- Type and final molarity of buffer: 0.05M phosphate buffer
- pH: 9
- Type and final molarity of buffer: 0.05M borate buffer - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: Amber glass vials with PTFE seals were used as test vessels
The test was carried using a thermostatically controlled enclosure at ¿ 0.5 ºC the chosen temperature, which was kept within ¿ 0.1 ºC. Photolytic interference was avoided all precautions were taken to exclude dissolved oxygen. - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 14.4 mg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 14.4 mg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 14.4 mg/L
- Number of replicates:
- Each sample was prepared in duplicate
- Preliminary study:
- A preliminary test was performed with sufficient number of samples in order to be able to estimate whether the hydrolysis was lower than 10 % after 120 hours or not
- Transformation products:
- no
- % Recovery:
- 95.6
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 99.3
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 99.3
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- ca. 91 d
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- ca. 477 d
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- ca. 425 d
- Type:
- (pseudo-)first order (= half-life)
- Executive summary:
A GLP guideline study (OECD 111) is available for this test substance. The hydrolytic stability of Diuron under abiotic conditions is not dependent on pH. The degradation of Diuron being less 10 % at Ph 4, 7 and 9 and the corresponding half life at ambient temperature (calculated using Arrhenuis equation) estimated to be longer than 1 yr.
Reference
Almost no degradation of Diuron at the tested pH was observed to occur
Table 1: Time course of Diuron tech. concentrations at 50 ºC and different pH values |
|||||||||
|
pH 4 |
pH 7 |
pH 9 |
||||||
Time [h] |
pH |
[mg/L] |
[%] of initial |
pH |
[mg/L] |
[%] of initial |
pH |
[mg/L] |
[%] of initial |
0 |
4.01 |
13.7 |
100 |
7.01 |
14.4 |
100 |
9.01 |
14.0 |
100 |
2 |
4.01 |
13.7 |
100 |
- |
- |
- |
9.01 |
14.0 |
100 |
4 |
4.02 |
13.7 |
100 |
- |
- |
- |
9.01 |
14.0 |
100 |
6 |
4.02 |
13.7 |
100 |
7.01 |
14.4 |
100 |
9.01 |
14.0 |
100 |
24 |
4.01 |
13.7 |
100 |
7.00 |
14.4 |
100 |
9.01 |
14.0 |
100 |
48 |
4.01 |
13.6 |
99.3 |
7.02 |
14.4 |
100 |
9.00 |
14.0 |
100 |
75 |
4.01 |
13.6 |
99.3 |
7.01 |
14.4 |
100 |
9.02 |
13.9 |
99.3 |
96 |
- |
- |
- |
7.02 |
14.3 |
99.3 |
- |
- |
- |
120 |
4.02 |
13.1 |
95.6 |
7.02 |
14.3 |
99.3 |
9.01 |
13.9 |
99.3 |
Table 2: Degradation rate and half-life of Diuron tech. at 25 ºC / 50 ºC and different pH values * |
|||
Temperature [ ºC] |
pH |
Kobs |
t1/2 |
25 |
4 |
< 0.693 y-1 |
> 1 year |
50 |
4 |
0.00762 d-1 |
2181 hours |
25 |
7 |
< 0.693 y-1 |
> 1 year |
50 |
7 |
0.00145 d-1 |
11436 hours |
25 |
9 |
< 0.693 y-1 |
> 1 year |
50 |
9 |
0.00163 d-1 |
10206 hours |
* Degradation rate calculated according to Arrhenius equation |
Description of key information
Diuron is not susceptible to abiotic hydrolysis, is hydrolytically stable at pH 5, 7 and 9 for 120 hours at 50 °C, in the dark. Therefore, chemical hydrolysis can be excluded as a dissipation mechanism of Diuron in environmental systems.
Key value for chemical safety assessment
Additional information
A GLP guideline study (OECD 111) is available for this test substance. The hydrolytic stability of Diuron under abiotic conditions is not dependent on pH. The degradation of Diuron being less than 10 % at pH 4, 7 and 9 and the corresponding half life, at ambient temperature (calculated using Arrhenuis equation), estimated to be longer than 1 yr (Wilfinger, 2007)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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