Registration Dossier
Registration Dossier
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EC number: 204-669-1 | CAS number: 123-99-9
Endpoint summary
Administrative data
Description of key information
Additional information
The evaluation of the toxicity of azelaic acid to aquatic organisms is based on data obtained by acute and long-term toxicity studies conducted with species of three trophic levels. Since no reliable data on the toxicity of azelaic acid to are available the presented results refer to data on homologue fatty acids.
Studies on decanoic acid (CAS 334-48-5) were used as read across for studies on short-term toxicity to fish, aquatic invertebrates and aquatic algae as well as for studies on long-term aquatic invertebrates and toxicity to microorganisms. Furthermore studies on the toxicity of octanoic acid C8 (124-07-2) to aquatic algae and microorganisms were used for a read across. The data on the long-term toxicity to fish refer to sodium laurate (CAS 629-25-4)
All species of the three trophic levels show comparable sensitivity to in the acute toxicity tests. A LC50 (96h) > 16 mg/L (meas. geom. mean) was determined for fish. For aquatic invertebrates an EC50 (48h) of > 21 (meas. geom. mean) was reported. In long-term toxicity studies a NOEC of 2 mg/L based on mortality was determined in fish. For aquatic invertebrates a NOEC of 0.2 mg/L was detected for reproduction of Daphnia magna.
Concluding from the available studies, algae are regarded to be the most sensitive organisms in acute and chronic tests with an ErC50 for growth rate of 15 mg/L for the decanoic acid (CAS 334 -48 -5) and a NOEC for growth rate of 0.07 mg/L for the octanoic acid C8 (CAS 124 -07 -2). Those endpoints were taken into account for PNEC-calculations.
Microorganisms were not sensitive to azelaic acid. In studies on Pseudomonas putida an EC0 value of 3000 mg/L was determined for decanoic acid and an EC10 of 912 mg/L was detected for octanoic acid. The PNEC assessment was based on the EC10 of 912 mg/L.
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