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Diss Factsheets
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EC number: 231-710-0 | CAS number: 7695-91-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Mutagenicity of Tocopheryl Quinones: Evolutionary Advantage of Selective Accumulation of Dietary alpha-Tocopherol.
- Author:
- Cornwell DG et al
- Year:
- 2 002
- Bibliographic source:
- Nutr Cancer 43 (1): 111-118
Materials and methods
- Principles of method if other than guideline:
- Method: other: according to Tindall KR and Stankowski LF (1989). Mutat Res 220: 241-253
- GLP compliance:
- not specified
- Type of assay:
- mammalian cell gene mutation assay
Test material
- Reference substance name:
- 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol
- EC Number:
- 231-523-4
- EC Name:
- 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol
- Cas Number:
- 7616-22-0
- IUPAC Name:
- 2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol
- Details on test material:
- d-gamma-tocopherol; according to the authors, purity was 92.6% (no data on contaminants)
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Chinese hamster ovary AS52 cells
- Additional strain / cell type characteristics:
- other: AS52 cells: cells which lack the normal X-like mammalian hypoxanthine-guanine phosphoryltransferase (hprt) gene but contain a single functional copy of the E coli xanthin- guanine phosphoribosyltransferase (gpt) gene stably integrated into the genome.
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- ca. 2.9, 14.6 ug/ml (6.8, 34 uM)
- Details on test system and experimental conditions:
- Cells were incubated with the test substance at concentrations of 6.8 and 34 uM (ca. 2.9 and 14.6 ug/ml) for 5 hours.
Mutagenicity was expressed as an increase in the number of thioguanine-resistant (TGr) clones; cytotoxicity was determined by measuring the cloning efficiency. Untreated controls cultured in medium and solvent controls treated with the vehicle (ethanol) were included.
Results and discussion
Test results
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: ca. 14.6 ug/ml (34 uM)
- Additional information on results:
- The test substance had no effect on mutant frequency. A significant decrease in cloning efficiency was observed at the high concentration when compared with controls; relative cloning efficiency was approximately 85-90% (control = 100%). The results of the cytotoxicity study are presented only graphically; no further data.
- Remarks on result:
- other: other: Chinese hamster ovary AS52 cells
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.