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Diss Factsheets
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EC number: 203-891-6 | CAS number: 111-64-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Octanoyl chloride
- EC Number:
- 203-891-6
- EC Name:
- Octanoyl chloride
- Cas Number:
- 111-64-8
- Molecular formula:
- C8H15ClO
- IUPAC Name:
- octanoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): N-OCTANSAEURECHLORID
- Physical state: liquid, colourless
- Analytical purity: 97% (by GC)
- Lot/batch No.: Vers. 62/V
- Stability under test conditions: test substance is sensitive to hydrolysis
- Storage condition of test material: room temperature, exclusion of moisture
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: DR. K. THOMAE GMBH, BIBERACH, D
- Age at study initiation: Young adult animals
- Weight at study initiation: 150-300 g (+-20% of the mean weight)
- Housing: single housing in stainless steel wire mesh cages
- Diet (e.g. ad libitum): KLIBA-LABORDIAET, KLINGENTAMUEHLE AG, KAISERAUGST, SWITZERLAND, AD LIBITUM
- Water (e.g. ad libitum): TAP WATER AD LIBITUM PER DAY
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10, 40%
MAXIMUM DOSE VOLUME APPLIED: 5 mL - Doses:
- 500 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: RECORDING OF SIGNS AND SYMPTOMS SEVERAL TIMES ON THE DAY OF ADMINISTRATION, AT LEAST ONCE EACH WORKDAY FOR THE INDIVIDUAL ANIMALS. INDIVIDUAL BODY WEIGHTS SHORTLY BEFORE APPLICATION (DAY 0), WEEKLY THEREAFTER AND AT THE END OF THE STUDY (BEFORE FASTING PERIOD). A CHECK FOR ANY DEAD OR MORIEBUND ANIMAL WAS MADE TWICE EACH WORKDAY AND ONCE ON SATURDAYS, SUNDAYS AND ON PUBLIC HOLIDAYS.
- Necropsy of survivors performed: yes
NECROPSY AT THE LAST DAY OF THE OBSERVATION PERIOD. WITHDRAWAL OF FOOD AT LEAST 16 HOURS BEFORE KILLING WITH CO2; THEN NECROPSY WITH GROSSPATHOLOGY EXAMINATION. NECROPSY OF ALL ANIMALS THAT DIED BEFORE AS EARLY AS POSSIBLE.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no mortality observed
- Clinical signs:
- other: SIGNS OF TOXICITY NOTED IN THE 2000 MG/KG DOSE GROUP AND IN THE FEMALE RATS OF TUE 500 MG/KG DOSE GROUP COMPRISED IMPAIRED OR POOR GENERAL STATE, DYSPNOEA, APATHY AND STAGGERING. ADDITIONALLY ATAXIA WAS OBSERVED IN 1 MALE ANIMAL OF THE 2000 MG/KG DOSE GRO
- Gross pathology:
- NO ABNORMALITIES WERE NOTED AT NECROPSY OF ANIMALS SACRIFICIED AT THE END OF THE STUDY.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.