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Diss Factsheets
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EC number: 271-231-4 | CAS number: 68526-83-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report equivalent or similar to OECD guideline 402: pre-GLP.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
- Reference Type:
- publication
- Title:
- Acute toxicity of a homologous series of branched chain primary alcohols
- Author:
- Scala RA and Burtis EG
- Year:
- 1 973
- Bibliographic source:
- Am Ind Hyg Assoc J 34:493-499
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Alcohols, C7-9-iso-, C8-rich
- EC Number:
- 271-231-4
- EC Name:
- Alcohols, C7-9-iso-, C8-rich
- Cas Number:
- 68526-83-0
- Molecular formula:
- CnH2n+1OH (n = 7 to 9)
- IUPAC Name:
- Branched alcohols, C7-9, C8 rich
- Details on test material:
- - Name of test material (as cited in study report): MRD-59-12
- Physical state: clear liquid with an unpleasant odor
- Analytical purity: considered to be 100%
Constituent 1
Test animals
- Species:
- rabbit
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: by exposure group
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: intact abdominal skin
- Type of wrap if used: gauze covered with a plastic sleeve
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Sponged with Fuller's earth
- Time after start of exposure: 24 h - Duration of exposure:
- 24 H
- Doses:
- 100, 316, 1000, 3160 ul/kg (83.2, 262, 832, 2629 mg/kg based on a density of 0.832 mg/cm3)
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 1, 4, and 24 hours and daily thereafter for a total of 7 days
- Statistics:
- No data analyzed.
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 2 632 mg/kg bw
- Mortality:
- 1 animal in the 3160 ul/kg exposure group died within 24 hours post patch removal. All other animals survived until the end of the observation period.
- Clinical signs:
- other: Within 4 hours of application, animals in the 3160 ul/kg exposure group exhibited signs of depressed physiologic function. All adverse observations were resolved within 2 days post exposure.
- Gross pathology:
- Gross autopsy performed in the animal which succumbed revealed congested kidneys and lungs. All other animals had unremarkable findings.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 of isooctanol is >2632 mg/kg.
- Executive summary:
In this study, rabbits were exposed to varying concentrations (100, 316, 1000, or 3160 ul/kg) of isooctanol via an occluded dermal patch for 24 hours. Observations were made at 1, 4, and 24 hours and daily thereafter for a total of 7 days. One animal in the highest dose group died within 24 hours of patch removal. All other animals survived. Within 4 hours of application, animals in the 3160 ul/kg exposure group exhibited signs of depressed physiologic function. All adverse observations were resolved within 2 days post exposure. It is concluded that the LD50 is greater than 3160 ul/kg (2632 mg/kg).
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