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Diss Factsheets
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EC number: 201-171-6 | CAS number: 79-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No GLP data and no guideline was followed. No reference substance was used, there is no information on the number of replicates and the number of observed metaphases was 100 instead of 200 as recommended in the guidelines.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
- Principles of method if other than guideline:
- A Chinese hamster lung fibroblast cell line (CHL) was used (Ishidate and Odashima, 1977). After a 6-h treatment, the ceils were rinsed with Dulbecco's PBS and recultured with fresh medium for another 18 h. The chromosome preparations were made using the standard air-drying method, and the frequency of the cells with chromosomal aberrations was scored in 100 well-spread metaphases for each concentration group.
- GLP compliance:
- not specified
- Type of assay:
- in vitro mammalian chromosome aberration test
Test material
- Reference substance name:
- Chloroacetyl chloride
- EC Number:
- 201-171-6
- EC Name:
- Chloroacetyl chloride
- Cas Number:
- 79-04-9
- Molecular formula:
- C2H2Cl2O
- IUPAC Name:
- 2-chloroacetyl chloride
- Details on test material:
- - Name of test material (as cited in study report): Chloroacetyl chloride
- Purity: > 99%
- Source: Aldrich Chemical Company. Inc.
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Chinese hamster lung fibroblast cell line (CHL)
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 mix
- Test concentrations with justification for top dose:
- 0, 0.06, 0.125, 0.25 and 0.5 mg/ml
Controls
- Untreated negative controls:
- yes
Results and discussion
Test results
- Species / strain:
- other: Chinese hamster lung fibroblast cell line (CHL)
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Untreated negative controls validity:
- valid
- Remarks on result:
- other: strain/cell type: Chinese hamster lung fibroblast cell line (CHL)
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Chloroacetyl chloride showed cytotoxicity at the highest concentration but did not induce chromosomal aberrations. - Executive summary:
A Chinese hamster lung fibroblast cell line (CHL) was used (Ishidate and Odashima, 1977). After a 6-h treatment, the ceils were rinsed with Dulbecco's PBS and recultured with fresh medium for another 18 h. The chromosome preparations were made using the standard air-drying method, and the frequency of the cells with chromosomal aberrations was scored in 100 well-spread metaphases for each concentration group. Chloroacetyl chloride showed cytotoxicity at the highest concentration but did not induce chromosomal aberrations.
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