Registration Dossier
Registration Dossier
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EC number: 436-000-6 | CAS number: 159010-67-0
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From April 3rd to 23rd, 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- 1981
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Blue REg 6080
- IUPAC Name:
- Blue REg 6080
Constituent 1
Study design
- Analytical monitoring:
- yes
- Details on test conditions:
- A preliminary test was performed at 50 ± 0.5 °C at each of pH 4, 7, 9.
Aliquots of each test solution were analysed in time intervals using the HPLC-UV analytical method. Analysis was performed before incubation, after 2.4 hours and after 120 hours.
- Number of replicates:
- Duplicate for each pH.
Results and discussion
- Preliminary study:
- The solubility of test item in buffer solution pH 4, 7 and 9 is very low. It was not possible to increase the soluble amount of test item with the use of solubilizer. Peak obtained, if any, are too small to allow quantification or even to follow a degradation curve.
As test item showed no significant solubility, no further testing was performed. - Transformation products:
- not measured
Dissipation DT50 of parent compound
- Remarks on result:
- not determinable
- Remarks:
- due to the low solubility of test item
- Details on results:
- No test could be performed. The solubility of the test item in the buffer solutions at pH 4, 7 and 9 is very low. It was not possible to increase the soluble amount of the substance by the use of a solubilizer. Peak obtained, if any, are too small to allow quantification or even to follow a degradation curve.
Applicant's summary and conclusion
- Conclusions:
- No test could be performed as test item has too little water solubility to be evaluated for hydrolytic stability under test conditions.
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