2-bromo-2-methylpropionyl bromide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2003

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

2-bromo-2-methylpropionyl bromide

EC Number:

244-017-3

EC Name:

2-bromo-2-methylpropionyl bromide

Cas Number:

20769-85-1

Molecular formula:

C4H6Br2O

IUPAC Name:

2-bromo-2-methylpropanoyl bromide

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

female

Administration / exposure

Route of administration:

oral: drinking water

Vehicle:

other: undiluted for level 2000 mg/kg bw, as a solution in arachid oil for level 300 mg/kg bw

Doses:

Single administration

No. of animals per sex per dose:

3 femals per dose

Control animals:

yes

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

>= 300 - <= 500 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The acute oral median lethal dose (LD50) of the test material in the female Sprague-Drawley CD strain rat was estimated to be in the range of 300-500 mg/kg bodyweight.