Registration Dossier
Registration Dossier
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EC number: 244-334-7 | CAS number: 21324-40-3
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Information on major hydrolysis product of the registered substance (released rapidly on contact with water/moisture).
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Authoritative review of fluoride exposure, toxicokinetics and toxicity by an expert committee.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Fluoride in Drinking Water: A Scientific Review of EPA's Standards
- Author:
- Committee on Fluoride in Drinking Water, NRC
- Year:
- 2 006
- Bibliographic source:
- US National Academy of Sciences
Materials and methods
- Principles of method if other than guideline:
- Detailed expert review of fluoride, addressing all aspects related to possible adverse effects of its presence in drinking water.
Test material
- Reference substance name:
- Hydrogen fluoride
- EC Number:
- 231-634-8
- EC Name:
- Hydrogen fluoride
- Cas Number:
- 7664-39-3
- IUPAC Name:
- fluoride
- Details on test material:
- Fluoride is a major hydrolysis product of the rapid reaction of LiPF6 with water.
Constituent 1
Test animals
- Species:
- other: Data obtained from both animals and man reviewed
Results and discussion
Any other information on results incl. tables
Hydrogen fluoride is formed from ingested fluoride in the stomach, and is the principal form in which fluoride is absorbed here; it passes easily through the gastric epithelium. Dissociation to free fluoride (F-) follows. Fluoride half-life in the GI tract is about 30 minutes, with high absorption efficiency (typically 70 – 90%: nearly 100% for soluble inorganic fluorides). It becomes incorporated in skeletal bone and in teeth (some 99% of the total body fluoride being within bone). The general pattern of absorption and distribution appears generally similar in animals and man, but it has been observed that rats may require higher chronic exposure to fluoride to achieve comparable plasma and bone concentrations: about 5 times higher concentration in water to establish similar plasma concentrations; incorporation into bone about 18 times more in man than in rats under normal dietary conditions.
Applicant's summary and conclusion
- Conclusions:
- Excessive intake of fluoride can lead to fluorosis of the dental enamel or skeletal bone due to retention and accumulation in these body parts.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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