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EC number: 206-059-0 | CAS number: 298-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-05-28 to 1993 to 1993-06-01
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, comparable to guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA Guideline 72-1 (national standard, US, comparable to international guidelines)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Test solutions were analysed at test initiation (0 hour) and at test termination (96 hours).
- Vehicle:
- no
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: Mount Lassen Trout Farm, Red Bluff, California
- Length at study initiation (length definition, mean, range and SD): mean: 40 mm (range: 32 - 45 mm, N=30)
- Weight at study initiation (mean and range, SD): mean wet weight: 0.52 g (range: 0.40 - 0.65, N=30)
- Method of breeding: not reported
- Feeding during test: yes
ACCLIMATION: fish were maintained under conditions similar to test conditions for 14 days prior to testing - Test type:
- flow-through
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Hardness:
- Total hardness as CaCO3: 23 - 27 mg/L
- Test temperature:
- 12±1°C
- pH:
- 6.9 - 7.0
- Nominal and measured concentrations:
- nominal test concentrations: 160, 260, 430, 720, 1200 and 2000 mg/L
mean measured concentrations: 160, 270, 430, 690, 1200 and 1900 mg a.i./L - Details on test conditions:
- TEST SYSTEM
- Test vessel: aquaria
- Type: open / closed: not reported
- Material, size, headspace, fill volume: not reported
- Aeration:
- Type of flow-through (e.g. peristaltic or proportional diluter): intermittent-flow proportional diluter apparatus
- Renewal rate of test solution (frequency/flow rate): 6.6 aquarium volumes per day
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: not reported
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Well water
- Total organic carbon: 0.82 - 1.5 mg/L
- Conductivity: 110 - 120 μmhos/cm
- Culture medium different from test medium: no
- Intervals of water quality measurement: monthly TOC analysis
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality
TEST CONCENTRATIONS: Not reported, only excerpts of study report available
OTHER TEST CONDITIONS
- Adjustment of pH: not reported
- Photoperiod: 16 hours light, 8 hours dark
- Light intensity: 20 to 100 footcandles throughout the study period
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1 300 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL: 1200 - 1900 mg/L
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 430 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Reported statistics and error estimates:
- LC 50 was estimated by nonlinear interpolation
95% interval calculated by binominal probability - Sublethal observations / clinical signs:
Table 1: Test results
Exposure time[h]
LC50[mg/L]a
95% Confidence interval
NOECa
96
1300c
1200 - 1900
430
72
1400c
1200 - 1900
-
48
1400c
1200 - 1900
-
24
1500b
1300 - 1700
-
aBased on mean measured concentrations expressed as Potassium Bicarbonate
bLC50 value and 95% confidence interval calculated by probit analysis
cLC50 value estimated by nonlinear interpolation; 95% confidence interval calculated by binominal probability
Following 48 hours of exposure, 100% mortality was observed among fish exposed to the highest mean measured concentration tested (1900 mg/L). At test termination (96 hours), mortality of 35% was observed among fish exposed to 1200 mg/L treatment level.
No mortality was observed among fish exposed to the remaining concentrations tested (160 to 690 mg/L).
Sublethal effects (i.e., partial loss of equilibrium, erratic swimming behaviour) were observed among two of the surviving fish exposed to the 690 and 1200 mg/L treatment levels.
- Validity criteria fulfilled:
- not specified
- Remarks:
- Not reported, only excerpts of study report available)
- Conclusions:
- In a 96-h acute toxicity study according to national guideline FIFRA Guideline 72-1 the 96-h LC50 for Rainbow trouts (Oncorhynchus mykiss) was 1300 mg a.i./L (95% CL: 1200 - 1900 mg a.i./L). The NOEC, based on mortality, was 430 mg a.i./L.
- Executive summary:
In a 96-h acute toxicity study according to national guideline FIFRA Guideline 72-1, Rainbow trouts (Oncorhynchus mykiss) were exposed to Potassium carbonate at measured concentrations of 160, 270, 430, 690, 1200 and 1900 mg a.i./L under flow through conditions. The 96-h LC50was 1300 mg a.i./L. The NOEC, based on mortality, was 430 mg a.i./L.
This toxicity study is classified as reliable with restrictions and satisfies the guideline requirement for acute toxicity study to fish.
Results Synopsis
Test organism size : mean length: 40 mm (range: 32 - 45 mm, N=30)
mean wet weight: 0.52 g (range: 0.40 – 0.65, N=30)
Test Type (Flow through): FIFRA Guideline 72-1
LC50: 1300 mg a.i./L 95% CL: 1200 - 1900 mg a.i./L
NOEC: 430mg a.i./L
Endpoint(s) Effected: mortality
Reference
Description of key information
The 96-h LC50 for Rainbow trout is 1300 mg a.i./L. The NOEC, based on mortality, is 430 mg a.i./L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 300 mg/L
Additional information
In a 96-h acute toxicity study according to national guideline FIFRA Guideline 72-1 the 96-h LC50 for Rainbow trouts (Oncorhynchus mykiss) was 1300 mg a.i./L (95% CL: 1200 - 1900 mg a.i./L). The NOEC, based on mortality, was 430 mg a.i./L.
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