Registration Dossier
Registration Dossier
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EC number: 213-928-8 | CAS number: 1067-33-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 111
- Deviations:
- yes
- Principles of method if other than guideline:
- only at garstic pH (1.2)
Test material
- Reference substance name:
- Dibutyltin di(acetate)
- EC Number:
- 213-928-8
- EC Name:
- Dibutyltin di(acetate)
- Cas Number:
- 1067-33-0
- Molecular formula:
- C12H24O4Sn
- IUPAC Name:
- dibutyltin di(acetate)
- Details on test material:
- - Name of test material : dibutyltin acetate Bu2Sn(OAc)2
- Radiochemical purity (if radiolabelling): >99 %
- Specific activity (if radiolabelling): 6.3 Ci/mmol
Unlabeled R2Sn (OAc)2, derivatives (prepared as needed by photodecomposition of R4Sn compounds on silica gel chromatoplates and TLC isolation); 1-14C-labeled preparations of Bu2Sn(OAc), with a specific activity of 6.3 mCi/mmol, and >99% radiochemical purity
- Name of test material : Bu2SnCl2 (unlabelled Bu2SnX2)
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: n.a., in vitro
- Strain:
- not specified
Administration / exposure
- Route of administration:
- not specified
- Vehicle:
- water
Doses / concentrations
- Dose / conc.:
- 0.01 other: mol /L
- Control animals:
- no
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- Hydrolysis Product: Dimeric Distannoxane, no Dibutyltin dichlorid detected
Metabolite characterisation studies
- Metabolites identified:
- yes
Applicant's summary and conclusion
- Conclusions:
- The dimeric distannoxane [(DBTC)2O]2 is the only in-vitro metabolite of DBTAc under the conditions of the study. Spectral data as well as melting point match very well with literature data (Davies 2004).
Dibutyltin dichloride (DBTC) – not even in traces - could not be detected in the reaction product.
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