long chain alkyl thio carbamide metal complex

Endpoint summary

Description of key information

The acute oral LD50 is >2,000 mg/kg bw.
The acute dermal LD50 is >2,000 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

2 000 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

LD50

Value:

2 000 mg/kg bw

Additional information

In accordance with the Specific Rules for Adaptation laid down in Annex VIII of REACH, a study of the acute inhalation toxicity of the substance is not required, since the potential for inhalation exposure to occur is considered negligible and studies of acute toxicity via oral exposure and via dermal exposure have been provided.

Justification for classification or non-classification

The acute oral LD50 is >2,000 mg/kg; therefore, no classification for acute oral toxicity is required according to both DSD and CLP.

The acute dermal LD50 is >2,000 mg/kg bw; therefore, no classification for acute dermal toxicity is required according to both DSD and CLP.

No acute inhalation toxicity data are available. Based on the low acute systemic toxicity via both the oral and dermal routes of exposure, no classification for acute inhalation toxicity is proposed.

In the acute oral toxicity study, the only clinical signs were wet rales in one animal from the one-hour observation to the Day 2 observation, and alopecia of the trunk in one animal from Day 4 to study termination. There were no remarkable body weight effects or gross pathology findings. In the acute dermal toxicity study, adverse effects were limited to local irritation effects of the skin at the site of application. Consequently, no classification for Single Exposure Specific Target Organ Toxicity is required under CLP.