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Diss Factsheets
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EC number: 263-753-6 | CAS number: 62899-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to EU /OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Two (technical) deviations from the study plan had no influence in the results of the study:
1. Dosing was altered depending on the actual development of mortality.
2. The post exposure observation period was prolonged to 21 days. - GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
Test material
- Reference substance name:
- Cyclohexylethylcarbamoyl chloride
- EC Number:
- 263-753-6
- EC Name:
- Cyclohexylethylcarbamoyl chloride
- Cas Number:
- 62899-75-6
- Molecular formula:
- C9H16ClNO
- IUPAC Name:
- N-cyclohexyl-N-ethylcarbamoyl chloride
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 580 mg/m3
880 mg/m3
1390 mg/m3 - No. of animals per sex per dose:
- 5 male, 5 female
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 880 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- In all groups mortality occurred 7 - 9 days after exposure.
- Clinical signs:
- other: Main signs of clinical intoxication in all groups were lethargy, dyspnoe, partly combined with breathing sounds and salivation. Additionally in the medium and high dose group sneezing occurred and in the high dose group tremor was observed for about 2 day
- Body weight:
- Body weight decreased up to day 3 in the low dose group and up to day 7 in the medium and high dose group. After this time body weight increased but did not reach normal values up to day 21.
- Gross pathology:
- In the test substance treated groups of this study during necropsy all but one lungs of the rats were bloated to a dose dependent degree.
In the low dose group 8 lungs were bloated slightly and 1 moderately. 1 lung had additionally small white areas, up to 1 mm in diameter and the only lung which was not bloated had 1 grey glassy area, about 1 mm in diameter. The liver of one female had 2 deformed lobes, a 3rd lobe had one white area, about 2 mm in diameter. In the medium dose group 3 of the lungs were bloated slightly, 5 moderate and 2 severe. 1 lung was pinkish coloured, another one showed multiple bright-red areas and a third one diffuse brownred areas. In 2 male rats the lung associated lymph nodes were enlarged. In one male and female each thymus had dark-red areas up to 1 mm in diameter. In the high dose group 1 lung was bloated moderately and the other 9 severe. 4 of the lungs were more or less pinkish, one had dark-red areas up to 5 mm in diameter. The lung associated lymph nodes were dark-red in one male and enlarged in an other male. In one female thymus was edematous.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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