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EC number: 222-960-1 | CAS number: 3681-71-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 August 1995- 07 February 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Guidelines, Annex V Methods (Directive 92/69/EEC of 31 July 1992)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (Z)-hex-3-enyl acetate
- EC Number:
- 222-960-1
- EC Name:
- (Z)-hex-3-enyl acetate
- Cas Number:
- 3681-71-8
- Molecular formula:
- C8H14O2
- IUPAC Name:
- (Z)-hex-3-enyl acetate
- Details on test material:
- - Name of test material (as cited in study report): Hexenyl acetate cis and trans
- Substance type: no data
- Physical state: yellow liquid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data
- Isomers composition: no data
- Purity test date: no data
- Lot/batch No.: 248859
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: stored in the dark under ambient conditions
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Olac Limited, Shaw's Farm, Blackthorn, Bicester, OX6 0TP
- Age at study initiation: yound adult
- Weight at study initiation: 3.36- 3.56 kg
- Housing: the rabbits were housed individually in aluminium cages (48 x 61 x 46 cm) with grid floors beneath which were absorbent paper lined trays. Floors, cage racks, walls and ceilings were cleaned with disinfectant solution (0.5 % Tego 2000, Th Goldschmidt and Company Limited) as necessary.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 6 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-20
- Humidity (%): 61
- Air changes (per hr): 15-20
- Photoperiod (hrs dark / hrs light): 12/ 12
IN-LIFE DATES: From: 28 September 1995 To: 12 October 1995
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): 0.5 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- 1, 24, 48, 72 h continuing up to 14 d
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm
- % coverage:
- Type of wrap if used: The patch of gauze was covered with Micropore tape and the trunk was loosely bound with Elastoplast Elastic Bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): skin wiped with water
- Time after start of exposure: 4 h
SCORING SYSTEM
Erythema and Eschar Formation:
No erythema: 0
Very slight erythema (barely perceptible): 1
Well defined erythema: 2
Moderate to severe erythema: 3
Severe erythema (beet redness) to slight eschar formation (injuries in depth): 4
Oedema formation:
No oedema: 0
Very slight oedema (barely perceptible): 1
Slight oedema (edges of area well defined by definite raising): 2
Moderate oedema (area raised approximately 1 mm): 3
Severe oedema (area raised by more than 1 mm and extending beyond area of exposure): 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- Animal 1
- Time point:
- other: 24 h, 48 h, 72 h
- Score:
- 1
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- Animal 2
- Time point:
- other: 24 h, 48 h, 72 h
- Score:
- 1.3
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- Animal 3
- Time point:
- other: 24 h, 48 h, 72 h
- Score:
- 1
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- Animal 1
- Time point:
- other: 24 h, 48 h, 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- Animal 2
- Time point:
- other: 24 h, 48 h, 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- Animal 3
- Time point:
- other: 24 h, 48 h, 72 h
- Score:
- 0
- Irritant / corrosive response data:
- All animals showed slight erythema from 1- 72 h after patch removal. In 1 animal an increase to more definite erythema was noted at 24 h after patch removal. This animal continued to show slight erythema for 14 d after patch removal, with the skin becoming dry and flaky at the test site after 13 d.
No oedema was noted during the observation period.
Any other information on results incl. tables
Hexenyl acetate cis and trans acute dermal irritation test in rabbits reaction scores
Rabbit |
Erythema |
|||||||||
1 h |
24 h |
48 h |
72 h |
4 d |
7 d |
10 d |
11 d |
13 d |
14 d |
|
301 |
1 |
1 |
1 |
1 |
0 |
0 |
0 |
0 |
- |
- |
302 |
1 |
2 |
1 |
1 |
1 |
1 |
1 |
1 |
1* |
1* |
303 |
1 |
1 |
1 |
1 |
0 |
0 |
0 |
0 |
- |
- |
Rabbit |
Oedema |
|||||||||
1 h |
24 h |
48 h |
72 h |
4 d |
7 d |
10 d |
11 d |
13 d |
14 d |
|
301 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
- |
302 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
303 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
- |
Animals were shaved at 11 days after patch removal
h = hours after patch removal
d = days after patch removal
* = skin dry and flaky at test site
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance was assessed for acute dermal irritation according to OECD guideline 404. The test substance is classifed as not irritating although it was found to be a mild irritant to rabbit skin under the conditions of this test.
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