Registration Dossier
Registration Dossier
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EC number: 230-804-9 | CAS number: 7327-60-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- other: QSAR
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- March 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Generally recogized OECD toolbox was used to establish skin sensitising properties
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR analysis was done using the OECD toolbox.
- GLP compliance:
- no
- Type of study:
- other: OECD toolbox
Test material
- Reference substance name:
- Nitrilotriacetonitrile
- EC Number:
- 230-804-9
- EC Name:
- Nitrilotriacetonitrile
- Cas Number:
- 7327-60-8
- Molecular formula:
- C6H6N4
- IUPAC Name:
- 2-[bis(cyanomethyl)amino]acetonitrile
Constituent 1
In vivo test system
Test animals
- Species:
- other: QSAR
- Strain:
- other: QSAR
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: QSAR
- Vehicle:
- other: QSAR
- Concentration / amount:
- Not applicable
Challengeopen allclose all
- Route:
- other: QSAR
- Vehicle:
- other: QSAR
- Concentration / amount:
- Not applicable
- No. of animals per dose:
- Not applicable
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: QSAR
- Hours after challenge:
- 0
- Group:
- other: QSAR
- Dose level:
- not applicable
- No. with + reactions:
- 0
- Total no. in group:
- 0
- Clinical observations:
- based on chemical structure, skin sensitisation is not very likely
- Remarks on result:
- other: Reading: other: QSAR. . Hours after challenge: 0.0. Group: other: QSAR. Dose level: not applicable. No with. + reactions: 0.0. Total no. in groups: 0.0. Clinical observations: based on chemical structure, skin sensitisation is not very likely.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Based on QSAR, it is very unlikely that NTAN has skin sensitising properties.
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