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Diss Factsheets
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EC number: 236-743-4 | CAS number: 13472-45-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Remarks:
- other: no data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- This is brief summary of a study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of subcutaneous injections of sodium tungstate on the rat.
- Author:
- Selle RM.
- Year:
- 1 942
- Bibliographic source:
- Federation Proceedings. Part I, Vol. 1, The American Society for Pharmacology and Experimental Therapeutics, Page 165.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The toxicity of repeat subcutanaeous dosing of sodium tungstate to rats was assessed.
- GLP compliance:
- no
Test material
- Reference substance name:
- Disodium wolframate
- EC Number:
- 236-743-4
- EC Name:
- Disodium wolframate
- Cas Number:
- 13472-45-2
- Molecular formula:
- Na2WO4
- IUPAC Name:
- disodium dioxotungstenbis(olate)
- Details on test material:
- - Name of test material (as cited in study report): sodium tungstate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Details on exposure:
- - Male and female rats received daily doses of a 0.1 M aqueous solution of sodium tungstate at the rate of 0.05 cc per 10 grams of body weight.
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 M aqueous solution of sodium tungstate
- No. of animals per sex per dose:
- no data
- Control animals:
- yes
Examinations
- Statistics:
- no data
Results and discussion
Results of examinations
- Details on results:
- - Treated male rats weighed 26% less than the controls.
- In males, the kidneys were 45% heavier than the controls.
- In females, the kidney weights were 42% heavier than the controls although the body weight was 11% less than the controls.
- A severe drop in rectal temperature was observed in treated animals, from 100.7 to 92.5 ºF in 2 hours.
- After two hours the temperature slowly rose so that by 8 hours after the injection it had returned to 99.1 ºF.
- There were no differences between the weights of the bodies, kidneys, and adrenal glands of treated male and female rats and the control animals.
- Most of the tungsten was eliminated in the urine within 12 hours.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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