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EC number: 237-487-6 | CAS number: 13814-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1986-11-25 to 1986-12-11
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no GLP compliance, samples not moistened
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- adopted 1981-05-12
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tin(II) bis(methanesulfonate)
- EC Number:
- 401-640-7
- EC Name:
- Tin(II) bis(methanesulfonate)
- IUPAC Name:
- tin(II) bis(methanesulfonate)
- Reference substance name:
- 53408-94-9
- EC Number:
- 610-996-4
- Cas Number:
- 53408-94-9
- IUPAC Name:
- 53408-94-9
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Tin (II)-methane sulphonate (supplier: Riedel-de Haen AG, Seelze)
- Physical state: white, fine-grained powder
- Storage condition of test material: normal room temperature, in darkness
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harald Schriever, Kaninchenfarm, D-2740 Bremervörde, Neuendamm 88
- Weight at study initiation: males: 2.1 - 3.2 kg; females: 2.25 - 2.5 kg
- Housing: single caging in battery of cages with paper roll disposal system; size: 40 cm high, 45 cm wide, 50 cm long
- Diet (ad libitum): Ssniff Mü Z^R (Producer: Ssniff Spezialdiäten GmbH, 4770 Soest/Westfalen; Type: pellets, 1.0 - 1.5 cm large, 0.5 cm diameter
- Water (ad libitum): aqua fontana
- Acclimation period: 7 days at least
ENVIRONMENTAL CONDITIONS
- Temperature: 18 ± 2°C
- Relative humidity: 50 - 85%
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure/Type of wrap: prior to treatment the back of each animal was clipped (12 x 10 cm) with a small animal clipper. The animals' back of one group was abraded with clean clipper blade so as to penetrate the horny layer of the epidermis, but without causing bleeding. The animals back of the second group was left intact. After treatment the backs of all animals were secured with gauze pads, several wrappings of "Elastoplast" and "Stülpa" for 24 hours.
REMOVAL OF TEST SUBSTANCE
- Washing: the substance was removed with wet disposable gauze.
- Time after start of exposure: 24 hours - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3 males / 3 females (scarified skin)
3 males / 3 females (intact skin) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the evaluation of the clinical-toxicological sings (a modified Irving-Screening by Screnning methods in pharmacology, R.A. Turner, 1965) is done individually and depends on the nature of the sings.
Records were made according to the following intervals: 1 h, 2 + 3 h, 6 h, 24/48 h, 3/14 days post administration.
The skin alterations are recorded once daily after termination of the time of exposition for the entire observations period of 14 days. The scoring was done according to the Draize scale.
The body weights are recorded at day 0 (beginning of the experiment) and at day 14 (terminal necropsy) on the survivng animals.
- Necropsy of survivors performed: yes
Immediately after death a complete necropsy is performed on all acute- and late mortalities.
At the end of the 14-day observation period all surviving animals of all groups are sacrificed and gross necropsies are performed. - Statistics:
- no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: intact skin
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: scarified skin
- Mortality:
- No mortalities were observed
- Clinical signs:
- other: The sample did not induce any clinical-toxicological symptoms
- Gross pathology:
- Necropsies performed on all animals at termination exhibited no gross pathological findings
- Other findings:
- No skin alterations were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 (male/female rats)> 2000 mg/kg bw
According to the EC-Commission directive 67/548/EEC and its subsequent amendments, tin(II) methanesulphonate is not classified as acute toxic via the dermal route.
According to the EC-Regulation 1272/2008 and subsequent regulations, tin(II) methanesulphonate is not classified as acute toxic via the dermal route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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