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EC number: 238-969-9 | CAS number: 14901-07-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance material review on b-ionone
- Author:
- Ide, I., Toki, S.,
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007);Ide, I., Toki, S., 1970. Metabolism of b-ionone. Isolation, characterization and identification of the metabolites in the urine of rabbits. Biochemical Journal 119, 281–287.
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from J.Food and Chemical Toxicology
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one
- EC Number:
- 238-969-9
- EC Name:
- 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one
- Cas Number:
- 14901-07-6
- Molecular formula:
- C13H20O
- IUPAC Name:
- 4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one
- Test material form:
- other: oily liquid
- Details on test material:
- -Name of test material (as cited in study report): 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one
- Substance type: Organic
- Physical state: liquid
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- male albino rabbit weighing about 3.0 kg at a dose of 1 g/kg/day
Administration / exposure
- Route of administration:
- other: by stomach tube
- Vehicle:
- other: gum Arabic
- Details on exposure:
- 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one (b-Ionone) in aqueous suspension with gum Arabic was administered by stomach tube to a male albino rabbit weighing about 3.0 kg at a dose of 1 g/kg/day for seven days. The total administered dose was 23 g.
- Duration and frequency of treatment / exposure:
- seven days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
23 g
- Control animals:
- not specified
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- Five free metabolites in urine was identified .These included 3-oxo-b-ionone, 3-oxo-b-ionol, dihydro-3-oxob- ionol, 3-hydroxy-b-ionol and unchanged b-ionone. Additionally, two glucuronides of b-ionol were detected.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- The results showed that there were five free metabolites in urine. These included 3-oxo-b-ionone, 3-oxo-b-ionol, dihydro-3-oxob-ionol, 3-hydroxy-b-ionol and unchanged b-ionone.Additionally, two glucuronides of b-ionol were detected.Glucuronides were hydrolyzed with b-glucuronidase and
were identified as the glucuronides of 3-oxo-b-ionol and dihydro-3-oxo-b-ionol.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Urine samples were extracted and analyzed for b-ionone and its metabolites. The results showed that there were five free metabolites in urine. These included 3-oxo-b-ionone, 3-oxo-b-ionol, dihydro-3-oxob-ionol, 3-hydroxy-b-ionol and unchangedb-ionone. Additionally, two glucuronides ofb-ionol were detected.Glucuronides were hydrolyzed withb-glucuronidase and were identified as the glucuronides of 3-oxo-b-ionol and dihydro-3-oxo-b-ionol. - Executive summary:
4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one (b-Ionone) in aqueous suspension with gum Arabic was administered by stomach tube to a male albino rabbit weighing about 3.0 kg at a dose of 1 g/kg/day for seven days. The total administered dose was 23 g. Urine was collected everyday during the dosing period and for 4 days after the last dose. Urine samples were extracted and analyzed forb-ionone and its metabolites. The results showed that there were five free metabolites in urine. These included 3-oxo-b-ionone, 3-oxo-b-ionol, dihydro-3-oxob-ionol, 3-hydroxy-b-ionol and unchangedb-ionone. Additionally, two glucuronides ofb-ionol were detected.Glucuronides were hydrolyzed withb-glucuronidase and were identified as the glucuronides of 3-oxo-b-ionol and dihydro-3-oxo-b-ionol
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