Registration Dossier
Registration Dossier
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EC number: 240-540-6 | CAS number: 16485-10-2
Endpoint summary
Administrative data
Description of key information
Additional information
The acute toxicity to fish was assessed with the read-across substance DL-Ethylpanthenol under static conditions to a nominal concentration of 100 mg/L. The LC50 was calculated to be > 100 mg/L.
In Annex IX of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity testing in fish shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on fish. According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or is assessed to be a PBT or vPvB. The hazard assessment of DL-Panthenol reveals neither a need to classify the substance as dangerous to the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. Therefore and for reasons of animal welfare a long-term toxicity testing in fish is not provided.
The acute toxicity to aquatic invertebrates was assessed with Daphnids exposed under static conditions to a nominal concentration of 100 mg/L. The LC50 was calculated to be > 100 mg/L (limit concentration). The NOEC was greater or equal 100 mg/L.
The long term toxicity to aquatic invertebrates was assessed with the read-across substance DL-Ethylpanthenol under semi-static conditions over a period of 21 days at concentration of 10 mg/L and 100 mg/L. The overall NOEC was determined to be greater or equal 100 mg/L. The LC 50 based on parental mortality was > 100 mg/L.
The toxicity to algae was assessed exposing algae under static conditions to a nominal concentration of 100 mg/L. The EC50 was calculated to be > 100 mg/L (nominal, limit concentration). The NOEC was greater or equal 100 mg/L.
The toxicity to microorganisms was assessed with the supporting substance DL-Ethylpanthenol at nominal concentrations of 100 mg/L for 3 hours. The EC50 was > 100 mg/L (nominal).
For justification of read across please refer to the attachment in IUCLID5 section 13.
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