Registration Dossier
Registration Dossier
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EC number: 938-774-5 | CAS number: 85408-49-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No studies investigating the toxicity to micro-organisms have been performed using C12 -16 amine oxide. Data are read across from C12-14 and C12-18 AO on the basis of the equivalence in chemical structure, large overlap in chain length distributions between the substances and expected similarities in physico-chemical properties.
C12-14 AO and C12-18 AO exhibit similar toxicity to Pseudomonas putida. The value of 24 mg AO/L from a study with C12-14 AO is used for the chemical safety assessment for C12-16 AO.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 24 mg/L
Additional information
No studies investigating the toxicity to micro-organisms have been performed using C12 -16 amine oxide. Data are read across from C12-14 and C12-18 AO on the basis of the equivalence in chemical structure, large overlap in chain length distributions between the substances and expected similarities in physico-chemical properties.
Reliable studies are available for both C12-14 and C12-18 AO.Pseudomonas putidawere exposed to nominal concentrations of 0, 50, 100, 1000, 10000 or 100000 mg/L of C12 -18 AO for 18 hours in a Bringmann-Kohn test [Kolvenbach M (1990b)]. The EC10, based on reduction in growth rate, was 29.8 mg/L. In a similarly performed study using C12 -14 AO, the EC10 was 24 mg AO/L [Kolvenbach M (1990a)].
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