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Diss Factsheets
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EC number: 200-293-7 | CAS number: 56-86-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The Ames test conducted on glutamic acid showed negative results.
Two Ames tests and two chromosomal aberration tests conducted on monosodium glutamate, an analogue substance showed negative results.
The in vivo micronucleus test showed that monosodium glutamate, an analogue substance, has no clastogenic activity in bone marrow cells of mice (negative).
Monosodium glutamate, an analogue substance, administration at levels up to 5.0% in the diet was not carcinogenic for male and female Fischer 344 rats in the carcinogenicity study.
Based on the results of the in vivo micronucleus test and the carcinogenicity study, the mouse lymphoma study does not appear scientifically necessary.
Short description of key information:
Based on an Ames test (according to OECD 471 and GLP) conducted on glutamic acid and read across from monosodium glutamate (EC 205-538-1):
Monosodium glutamate, an anlogue substance, has been tested in two bacterial reverse mutation tests (equivalent to OECD 471 and GLP), two chromosomal aberration tests (equivalent to OECD 473 and GLP), in vivo micronucleus test (equivalent to OECD 474 and GLP) and carcinogenicity data.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the information in the discussion mentioned above, the substance is not classified for mutagenicity according to DSD and CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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