Registration Dossier
Registration Dossier
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EC number: 429-290-0 | CAS number: 3380-30-1
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study performed with scientific authoritative method and in compliance with GLP. This study was intended to determine the solubility of test item in water, in n-hexane and in n-octanol at 3 different temperatures (10°C, 20°C and 30°C).The Kow of test item at those three temperatures was calculated from the solubility of test item in water and in n-octanol.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
- Principles of method if other than guideline:
- The solubility of test item was determined by suspending an excess of the compound in the buffer and in the solvents n-hexane and n-octanol,and stirring the suspensions in a thermostatted water bath for 3 days. The concentration in the filtered solutions was then determined by HPLC analysis with a UV detector by the method of external calibration. The Kow was then determined by calculation.
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 429-290-0
- EC Name:
- -
- Cas Number:
- 3380-30-1
- Molecular formula:
- C12 H8 Cl2 O2
- IUPAC Name:
- 5-chloro-2-(4-chlorophenoxy)phenol
- Details on test material:
- - Substance type: organic
- Physical state: solid
- Lot/batch No.: DCS LAB 006 07
Constituent 1
Results and discussion
- Test substance stable:
- not determined
Any other information on results incl. tables
Results:
| Solvent | Temperature | Solubility |
| n-hexan | 10°C | 8.7 mg/L |
| n-hexan | 20°C | 18.6 mg/L |
| n-hexan | 30°C | 27.0 mg/L |
| n-octanol | 10°C | 36.8 mg/L |
| n-octanol | 20°C | 43.7 mg/L |
| n-octanol | 30°C | 51.4 mg/L |
A trend can be seen, the solubility of test item increases with temperature
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
