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Diss Factsheets
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EC number: 251-118-6 | CAS number: 32588-76-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- 1,2-Bis-(tetrabromophthalimido)ethane
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: particulate/powder
- Reference substance:
- 1,2-Bis-(tetrabromophthalimido)ethane
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persitence. EBTBP has extremely limited solubility. For example, its estimated water solubility is 3.02 e-9 mg/L and its octanol solubiity as measured by total bromine content is approximately 0.45-0.60 mg/L. This limited solubility negatively affects its susceptibility to degradation. EBTBP is expected to have very limited availability to environmental bacteria, and, thus, degradation by this organisms will be limited by this fact alone. EBTBP is not readily biodegradable in the MITI test. A Level III Fugacity Model, based on chemical structure alone, estimates half-lives of 6.5 hr (air), 4320 hr (water), 8640 hr (soil) and 38900 hr (sediment) following emissions of 1000 kg/hr to each of air, water and soil. Overall persistence time is estimated at 5510 hrs or 7.6 months. That is, reaction with hydroxyl radicals in air is expected, and hydrolysis in water or biodegradation in soil and sediment is not expected. However, EBTBP has negligible vapor pressure such that degradation in air is not expected to be a significant route of environmental degradation. Further, EBPTBP's negligible water solubility,and limited paritioning to water indicate persistence in that media will not contribute substantially to its overall environmental persistence. EBTBP is expected to partition predominantly to soil, where it is expected to be very persistent (vP).
Bioaccumulation. EBTBP's insolubility, large molecular size, high molecular weight, and folded confrimation adversely affect its bioavailability. EBTBP's solubility in 1-octanol at room temperature, 0.45 -0.60 ppm, is less than 0.002 mmol/L x MW (REACH Guidance, Capter R11, page 32) or 1.90 mg/L. Based on this, EBTBP is not expected to accumulate in lipids. Additionally, EBTBP’s molecular weight is >700 and its maximum length ranges from 16.8 to 20 angstroms provides additional evidence for a lack of bioaccumulation. EBTBP did not bioconcentrate in fish when exposed via water.
Toxicity. EBTBP was not acutely toxic to orange-red killifish in a 48 hr test performed in Japan (LC50>500 ppm). EPI(v4.0) predicts EBTBP will not be acutely or chronically toxic to aquatic organisms due to its insolubility. No effects at saturation are predicted. EBTBP's estimated Log Kow is 9.79, which puts it above the cutoff value (Log Kow > 8.0) for toxicity. The estimates were based on the chemical structure alone. Additionally, no adverse effects were observed in prenatal developmentals sudies in rats and rabbits at doses up to 1000 mg/kg bw/d or in a 90-d study in rats at doses up to 1% in the diet. EBTBP is not classified as a carcinogen, mutagen or reproductive hazard.
- Likely routes of exposure:
The most likely route of exposure is in the workplace via inhalation when bulk bags of the product are emptied.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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