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EC number: 217-121-1 | CAS number: 1745-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Start of experiment: 14 January 1986 ; End of experiment 28 January 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP methodology followed and OECD guideline used to perfored the experiment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4,4'-isopropylidenebis[2-allylphenol]
- EC Number:
- 217-121-1
- EC Name:
- 4,4'-isopropylidenebis[2-allylphenol]
- Cas Number:
- 1745-89-7
- Molecular formula:
- C21H24O2
- IUPAC Name:
- 4-{1-[4-hydroxy-3-(prop-2-en-1-yl)phenyl]propyl}-2-(prop-2-en-1-yl)phenol
- Test material form:
- other: Viscous liquid.
- Details on test material:
- - Test substance: TK 11907
- Batch No.: Op. 1
- Generic name: XU 292 B
- Purity: Pilot-sample
- Physical properties: viscous liquid; insoluble in water
- Storage conditions: room temperature
- Validity: October 1991
- Safety precautions: gloves and face masks
- Test material received: November 19, 1985
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Test System
- The albino rabbit is the recommended species for skin irritation/corrosion studies
- Animal Strain : New Zealand white rabbits (KFM-NZW)
- Breeder: Kleintierfarm Madoerin AG, CH-4414 Fuellinsdorf
- Acclimatization period: 5 days
Group Size and Husbandry:
The test was performed on 3 male rabbits, checked for normal skin conditions, weighing between 2300 to 2520 g (approx. 12-14 weeks old) . The animals were housed individually in metal cages, identified with individually numbered ear tags, kept at a constant room temperature of 20+3 °C, at a relative humidity of 30-70 % and on a 12 hours light cycle day.
The rabbits received ad libitum Standard rabbit pellet - Nafag No. 814, Gossau, Switzerland - and fresh water.
The body weight was recorded at start and on days 3, 7, and 14 of the test.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: Both patches were moistened before application with distilled water containing 0.5% carboxymethylcellulose and 0.1% polysorbate 80.
- Controls:
- other: A control gauze patch was applied to the contrelateral flank.
- Amount / concentration applied:
- 0.5 grammes
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 3 males rabbits
- Details on study design:
- An area of at least 6 cm2 was shaved on both flanks of the animals approximately 24 hours before treatment. A gauze patch (20 cm2 hearing
0.5 g of the test substance was applied to the flank. A control gauze patch was applied to the contralaterall flank. Both gauze patches were moistened before application with dstilled water containing 0.5% carboxymethylcellulose and 0.1% polysorbate 80 (prepared by Pharmaceuticals Division, Ciba-Geigy L t d . ).
The patches were loosely covered with an aluminum foil (36 cm2 and held in place for 4 hours by an adhesive tape (Isoplast, Isoplast AG, CH-5200 Brugg).
SCORING SYSTEM:
Erythema and eschar formation
- No erythema: 0
- Very slight erythema (barely perceptible): 1
- Well defined erythema: 2
- Moderate to severe erythema: 3
- Severe erythema (beet redness) to slight eschar formation (injuries in depth): 4
Total possible erythema score 4
Edema formation
- No edema: 0
- Very slight edema (barely perceptible): 1
- Slight edema (edges of area well defined by definite raising): 2
- Moderate edema (raised approximately 1 mm): 3
- Severe edema (raised more than 1 mm and extending beyond area of exposure): 4
Total possible edema score 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- male
- Time point:
- 24/48/72 h
- Score:
- 2.66
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- male
- Time point:
- 24/48/72 h
- Score:
- 3.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- male
- Time point:
- 24/48/72 h
- Score:
- 2.66
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- male
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- male
- Time point:
- 24/48/72 h
- Score:
- 2.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- male
- Time point:
- 24/48/72 h
- Score:
- 2.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritant / corrosive response data:
- TK 11907 induced maximal irritant effects which were not reversible within 14 days.
It has to be concluded that TK 11907 has corrosive effects in albino rabbits.
Any other information on results incl. tables
Body weight (g):
Animal N° | 57 | 58 | 59 |
At start of test | 2520 | 2300 | 2370 |
Day 3 | 2600 | 2310 | 2450 |
Day 7 | 2730 | 2400 | 2580 |
Day 14 (end of test) | 2970 | 2580 | 2840 |
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the experimental conditions employed TK 11907 induced maximal skin irritation when applied to the clipped albino rabbit skin.
On account of the necrosis observed, full skin destruction is expected and, therefore, TK 11907 must be classified as corrosive. - Executive summary:
This acute skin irritation/corrosion study in albino rabbits (3 males) was performed to determine the irritant or corrosive potency of TK 11907 on the albino rabbit skin.
This test was based on the OECD guideline No. 404, adopted May 12, 1981, by the OECD council.
The test was performed under Good Laboratory Practice conditions and was subjected to periodical quality assurance evaluation.
Under the experimental conditions employed TK 11907 induced maximal skin irritation when applied to the clipped albino rabbit skin.
On account of the necrosis observed, full skin destruction is expected and, therefore, TK 11907 must be classified as corrosive.
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