Registration Dossier
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EC number: 202-878-2 | CAS number: 100-68-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In a study conducted by Verspeek-Rip (2010), the test substance, Thioanisole was tested in theSalmonella typhimuriumreverse mutation assay with four histidine requiring strains of Salmonella typhimurium (TA1535, TA1537, TA98 and TA100) and in theEscherichia colireverse mutation assay with a tryptophan-requiring strain of Escherichia coli (WP2uvrA). The test was performed in two independent experiments in the presence and absence of S9 -mix. Since in the second experiment in the tester strains TA1535, TA1537, TA98 and TA100 no toxicity or precipitate on the plates was observed, a third mutation experiment was performed with these strains in the absence and presence of 10 % (v/v) S9 -mix. The study was carried out to the most recent OECD and EC Guidelines.
All bacterial strains showed negative responses over the entire dose range. The negative and strain-specific positive control values were within the laboratory historical control data ranges indicating that the test conditions were adequate and that the metabolic activation system functioned properly. Based on the results of the study it is concluded that Thioanisole is not mutagenic, both in the presence and absence of metabolic activation, in the reverse mutation assay using Salmonella typhimurium and Escherichia coli. Under the conditions of this study, the test substance does not require classification according to Regulation EC No. 1272/2008 or according to Directive 67/548/EEC.
Short description of key information:
A single key study is available. Thioanisole was tested using four histidine requiring strains of Salmonella typhimurium (TA1535, TA1537, TA98 and TA100) and a tryptophan-requiring strain of Escherichia coli (WP2uvrA). The study was conducted using the reverse mutation assay.
All bacterial strains showed negative responses over the entire dose range. The negative and strain-specific positive control values were within the laboratory historical control data ranges indicating that the test conditions were adequate and that the metabolic activation system functioned properly. Based on the results of the study it is concluded that Thioanisole is not mutagenic, both in the presence and absence of metabolic activation, in the reverse mutation assay using Salmonella typhimurium and Escherichia coli.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the results of the key study, the test substance, Thioanisole, does not require classification according to Regulation EC No. 1272/2008 or Directive 67/548/EEC.
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