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EC number: 271-363-2 | CAS number: 68551-11-1 A complex combination of products produced by the distillation of products from the hydrogenation of butanal from the hydroformylation of propene. It consists predominantly of organic compounds such as aldehydes, alcohols, esters, ethers and carboxylic acids having carbon numbers in the range of C4-C32 and boiling in the range of approximately 143°C to 282°C (289°F to 540°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Male and female Wistar rats were administered orally (by gavage) to 5000 mg/kg bw and 2000 mg/kg bw test substance to determine the oral toxicity.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Oxooel 740 roh
- Substance type: product mixture
- Physical state: yellowish brown liquid
- Composition of test material, percentage of components: 2,2,4-trimethyIpentanediol-1,3-mono-i-butyrat / 2-ethylhexandiol-1,3 / 2,2-dimethylhexandiol-1,3-mono-i-butyrate: 33%, 2,2-dimethylhexanediol-1,3-di-i-butyrate / 2-ethyIhexanediol-1,3-mono-n-butyrate: 22%, 1-ethylpentenyl (2)-4-propyl-5,5 dimethyl-dioxane-1,3 / C8-diol-mono-i-butyrate: 14%, i-di-n-butylacetale / 2-ethylhexanol: 13%, 2,2-dimethylhexanediol-1,3: 8%, n-butanol: 3%, 2-ethylhexyl-n-butyrate: 1.5%, 2,4-di-propyl-5,5-dimethyl-dioxane-1,3: 1.5%, trimer-n-butyraldehyd: 1.0%, n-butyl-n-butyrate: 0.6%, 2,2,4-trimethylpentanediol-1,3: 0.3%, 2-ethyl-4-methylpentanediol-1,3-n-i-butyrate: 0.3%, 4-methyl-2-ethylpentanol: 0.2%, n-di-n-butylacetal: 0.2%, 2-ethylhexyl-i-butyrate: 0.2%, 4-methyl-2-ethylpentenal / 2-ethylhexanal: 0.1%, i-di-i-butylacetal: 0.1%, 2-i-propyl-4-propyl-5,5-dimethyl-dioxane-1,3: 0.02%, trimer-i-butyraldehyd: 0.01%, phosphor: 0.0013%, unknown substances: 3%, water: 0.1%
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH
- Weight at study initiation: - mean(males): 181 g (5000 mg/kg), 182 g (2000 mg/kg); - mean(females): 169 g (5000 mg/kg), 182 g (2000 mg/kg)
- Fasting period before study: 16 h
- Housing: 5 animals/cage
- Diet: ad libitum (KLIBA)
- Water: tap water ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 5000 mg/kg bw: 50% (w/v), 2000 mg/kg bw: 40% (w/v)
- Justification for choice of vehicle: substance is sensitive to hydrolysis
MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg bw: 10 mL/kg, 2000 mg/kg bw: 5 mL/kg
- Doses:
- 2000 mg/kg bw, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days;
- Frequency of observations and weighing: recording of signs and symptoms: several times on the day of administration, at least once each workday; check for moribund and dead animals: twice each workday and once on holidays;
- Necropsy of survivors performed: yes;
- Other examinations performed: body weights;
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- - 2000 mg/kg: males: 0/5, females: 0/5; - 5000 mg/kg: males: 1/5, females: 0/5
- Clinical signs:
- - males: dyspnea (30 min - 1 day), apathy (30 min - 1 day), abnormal position (1 h - 4 h), staggering (30 min - 1 day), atonia (1 h - 4 h), paresis (30 min - 4 h), pain reflex absent (1 h - 4 h), corneal reflex absent (1 h - 4 h), narcotic-like state (1 h - 4 h), spastic gait (1 day), piloerection (1 day - 3 days), exsiccosis (1 day), poor general state (30 min - 1 day);
- females: dyspnea (30 min - 4 h), apathy (30 min - 4 h), staggering (30 min - 4 h), paresis (1 h - 4 h), piloerection (1 day), poor general state (30 min - 4 h) - Body weight:
- - 5000 mg/kg: males: 197 g (day 3), 228 g (day 7), 264 g (day 13); females: 207 g (day 3), 219 g (day 7), 232 g (day 13); - 2000 mg/kg: males: 232 g (day 5), 241 g (day 7), 269 g (day 13); females: 216 g (day 5), 222 g (day 7). 227 g (day 13);
- Gross pathology:
- Male animal that died: general congestive hyperemia; sacrificed animals (males and females): no abnormalities detected
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- Oxooel 740 is practically non-toxic after oral administration.
- Executive summary:
Groups of 5 Wistar rats per sex and dose were administered 5000 mg/kg bw and 2000 mg/kg bw of the test substance, respectively. Only 1 male animal in the 5000 mg/kg bw group died. Clinical signs could be detected until day 3 after administration. The pathological observations showed a general congestive hyperemia in the dead male animal and no abnormalities in the sacrificed animals
Conclusion:
Oxooel 740 is practically non-toxic after oral administration.
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