Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 911-694-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics
- Adequacy of study:
- weight of evidence
- Objective of study:
- other: A toxicokinetic assessment has been performed based on physical chemical properties of the substance and available open literature.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A toxicokinetic assessment has been performed based on physical chemical properties of the substance and available open literature.
- GLP compliance:
- no
- Radiolabelling:
- no
- Route of administration:
- other: oral, dermal, inhalation
- Conclusions:
- Interpretation of results (migrated information): other: Based on the available data, oral, dermal and inhalation potenial absorption rates are are set to 100%
Based on the available data, oral, dermal and inhalation absorption rates are set to 100% for risk assessment. GF has no potential for bioaccumulation with log Kow <4. - Executive summary:
ABSORPTION
The partition coefficient of glycerol-formal is -0.99 with an estimated water solubility of 500 mg/L. This property of the substance is favorable for absorption.
- Oral/GI absorption
Low molecular weight of the substance is favorable for absorption. And the moderate log Kow value is favorable by passive diffusion.
For risk assessment purposes, the oral absorption is set at 100%. The results of the toxicity studies do not provide reason to deviate from this proposed oral absorption.
- Respiratory absorption-inhalation
With a vapor pressure of 0.03 kPa, GF shows a low volatility. The moderate log Kow value is favorable for absorption directly across the respiratory tract epithelium by passive diffusion.
For risk assessment purposes, the inhalation absorption is set at 100%. The results of the toxicity studies do not provide reason to deviate from this proposed inhalation absorption.
- Dermal absorption
As water solubility is > 10 g/L and the log Kow value is <1, GF may be too hydrophilic to cross the lipid rich environment of the stratum corneum. Dermal uptake is low for this kind of substance. The criteria for 10% dermal absorption as given in the TGD (3) (MW > 500 and log Pow < -1 or > 4) are not met, and hence a dermal absorption of 100% is proposed for risk assessment purposes.
DISTRIBUTION
Once absorbed, widely distribution of GF in the body is expected based on its low molecular weight.
Accumulative potential
With a log Kow < 4, GF has NO BIOACCUMULATIVE potential.
METABOLISM and EXCRETION
Based on the available data, no additional conclusions can be drawn on the metabolism and excretion of GF after dermal and inhalatory absorption.
Reference
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.