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EC number: 616-291-8 | CAS number: 76114-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997-02-17 to 1997-05-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented GLP based study according to EPA guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4500 (Acute Eye Irritation)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-propynyl-butylcarbamate
- EC Number:
- 616-291-8
- Cas Number:
- 76114-73-3
- Molecular formula:
- C8H13NO2
- IUPAC Name:
- 2-propynyl-butylcarbamate
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): only common name based on sponsor informaion is given, equivalent to:
Chemical name: Carbarmic acid, N-butyl-,2-propyn-1-yl ester
CAS: 76114-73-3
- Analytical purity: no data available
- Impurities (identity and concentrations): no data available
- Lot/batch No.: no data available
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Davidson Mil Breeding Labs, Jamesburg, NJ
- Age at study initiation: about 3 month
- Weight at study initiation: 1.5 - 2.0 kg
- Housing: stainless steel cages
- Diet: ad libitum Lab Diet Certified Rabbit Diet 5322
- Water: ad libitum
- Acclimation period: 5 days prior test initiation
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 65° to 75° F
- Humidity (%): monitored, but no detailed data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): single dose of 0.1 ml per eye (only one eye per rabbit)
-The contralateral eye, remaining untreated, served as control.
VEHICLE
- No vehicle, substance used as received - Duration of treatment / exposure:
- 24 hours (unwashed after application)
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 6 (3 males and 3 females)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: The eyes of all animals remained unwashed for 24 hours.
SCORING SYSTEM:
- According to Draize scale; mean daily scores were determined.
TOOL USED TO ASSESS SCORE: fluorescein sodium, hand held ophthalmoscope
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Total score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 7
- Irritation parameter:
- other: Total score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 1
- Irritation parameter:
- other: Total score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 0
- Irritation parameter:
- other: Total score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 0
- Irritant / corrosive response data:
- Shortly after injection (1 h), most rabbits showed effects in the Conjunctivae namely "vessels definitely above normal", "more diffuse, crimson red, individual vessels not easily discernible", "swelling above normal" and slight discharge. These effects subsided in all rabbits on the third day after substance application. Hence, the test item elicited minimal to mild conjunctival irritation. No fluorescin retention was noted at any interval.
- Other effects:
- The animals did not exhibit any abnormal clinical signs for the duration of the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information At 1 hour conjunctival redness = 2 in 4 out of 6 animals. However the score was less than 2 after 1 day and therefore, no classification is warranted in accordance with EU-CLP regulation table 3.3.2. Criteria used for interpretation of results: EU
- Conclusions:
- Propargyl-N-butylcarbamat elicited minimal to mild conjunctival irritation. No fluorescin retention was noted at any interval. The animals did not exhibit any abnormal clinical signs for the duration of the study.
- Executive summary:
The eye irritation of the test item Propargyl-N-butylcarbamat
was determined by investigation of the ocular irritation in rabbits according to the EPA guideline EPA OTS 798.4500 (Acute Eye Irritation). Shortly after injection (1 h), most rabbits showed effects in the Conjunctivae. These effects subsided in all rabbits on the third day after substance application. Hence, the test item elicited minimal to mild conjunctival irritation. No fluorescin retention was noted at any interval. Moreover, the animals did not exhibit any abnormal clinical signs for the duration of the study.
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