Registration Dossier
Registration Dossier
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EC number: 203-816-7 | CAS number: 110-93-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- ip toxicity study acc. internal BASF method
- GLP compliance:
- no
Test material
- Reference substance name:
- 6-methylhept-5-en-2-one
- EC Number:
- 203-816-7
- EC Name:
- 6-methylhept-5-en-2-one
- Cas Number:
- 110-93-0
- Molecular formula:
- C8H14O
- IUPAC Name:
- 6-methylhept-5-en-2-one
- Details on test material:
- - Name of test material (as cited in study report): 6-Methyl-5-hepten-2-one
- Analytical purity: 98 %
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean weight of 23.8 g (males) and 23.1 g (females)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- - administered as aqueous emulsions in CMC (supplemented with 2-3 drops Cremophor EL) at concentrations of 16, 8, 4 and 2% (v/v).
- Doses:
- 170, 340, 680 and 1360 mg/kg bw (ca. 0.2, 0.4, 0.8 and 1.6 ml/kg bw)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of weighing: prior to begin of study
- Necropsy of survivors performed: yes
- Other examinations performed: signs of pharmacologic or toxicologic effects
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 510 mg/kg bw
- Mortality:
- 1.6 ml/kg bw: 5/5 males and 4/5 females died within 24 hrs
0.8 ml/kg bw: 3/5 males and 4/5 females died within 24 hrs
0.4 ml/kg bw: 0/5 males and 3/5 females died within 7 days
0.2 ml/kg bw: 0/5 males and 0/5 females died within 7 days - Clinical signs:
- Abdominal position, staggering, apathy, atonia, dyspnoea
- Gross pathology:
- nothing abnormal detected
Any other information on results incl. tables
From these data a LD50 value of 0.6 ml/kg bw (= 510 mg/kg bw) after 7 days was estimated.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
