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Diss Factsheets
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EC number: 205-861-8 | CAS number: 156-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Calcium cyanamide
- EC Number:
- 205-861-8
- EC Name:
- Calcium cyanamide
- Cas Number:
- 156-62-7
- Molecular formula:
- CN2.Ca
- IUPAC Name:
- calcium cyanoazanediide
- Reference substance name:
- Calcium oxide
- EC Number:
- 215-138-9
- EC Name:
- Calcium oxide
- Cas Number:
- 1305-78-8
- Molecular formula:
- CaO
- IUPAC Name:
- oxocalcium
- Reference substance name:
- Carbon
- EC Number:
- 231-153-3
- EC Name:
- Carbon
- Cas Number:
- 7440-44-0
- Molecular formula:
- C
- IUPAC Name:
- carbon
- Reference substance name:
- Hematite (Fe2O3)
- EC Number:
- 215-275-4
- EC Name:
- Hematite (Fe2O3)
- Cas Number:
- 1317-60-8
- Molecular formula:
- Fe2O3
- IUPAC Name:
- diiron oxide
- Reference substance name:
- Urea
- EC Number:
- 200-315-5
- EC Name:
- Urea
- Cas Number:
- 57-13-6
- Molecular formula:
- CH4N2O
- IUPAC Name:
- urea
- Reference substance name:
- Silicon dioxide
- EC Number:
- 231-545-4
- EC Name:
- Silicon dioxide
- Cas Number:
- 7631-86-9
- Molecular formula:
- O2Si
- IUPAC Name:
- dioxosilane
- Reference substance name:
- Trisilicon tetranitride
- EC Number:
- 234-796-8
- EC Name:
- Trisilicon tetranitride
- Cas Number:
- 12033-89-5
- Molecular formula:
- N4Si3
- IUPAC Name:
- trisilicon tetranitride
- Reference substance name:
- Calcium dihydroxide
- EC Number:
- 215-137-3
- EC Name:
- Calcium dihydroxide
- Cas Number:
- 1305-62-0
- Molecular formula:
- CaH2O2
- IUPAC Name:
- calcium dihydroxide
- Reference substance name:
- Aluminium oxide
- EC Number:
- 215-691-6
- EC Name:
- Aluminium oxide
- Cas Number:
- 1344-28-1
- Molecular formula:
- Al2O3
- IUPAC Name:
- aluminium oxide
- Reference substance name:
- Cyanoguanidine
- EC Number:
- 207-312-8
- EC Name:
- Cyanoguanidine
- Cas Number:
- 461-58-5
- Molecular formula:
- C2H4N4
- IUPAC Name:
- 2-cyanoguanidine
- Reference substance name:
- Calcium acetylide
- EC Number:
- 200-848-3
- EC Name:
- Calcium acetylide
- Cas Number:
- 75-20-7
- Molecular formula:
- C2Ca
- IUPAC Name:
- calcium ethynediide
- Reference substance name:
- unknown
- IUPAC Name:
- unknown
- Test material form:
- solid: particulate/powder
- Details on test material:
- Kalkstickstoff (calcium cyanamide, technical grade)
Constituent 1
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
impurity 6
impurity 7
impurity 8
impurity 9
impurity 10
impurity 11
Test animals
- Species:
- rat
- Strain:
- other: Wistar derived, albino CPB-rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- A group of five male and five female SPF-rated, Wistar derived, albino CPB-rats, 9 weeks old, was used. The average weight of the males was 223 g, that of the females 153 g. After exposure the rats were returned to their living cages and provided with stock diet and tap water ad libitum during an observation period of 14 days.
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- The powdered substance was continuously dispersed in air by means of a "Wright" Dust Feed Mechanism at a maximum rate of 17 g/m3. The dustladen air was passed into a 1.5 m3 stainless steel exposure chamber in which the experimental animals were housed individually in wire-screen cages. The animals could be observed continuously through the hard glass entrance door. The temperature and relative humidity inside the exposure chamber were 23°C and 45-50% respectively.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- The concentration of the dispersed Kalkstickstoff was determined gravimetrically by passing a measured amount of the test atmosphere through a glassfibre filter. Particle size determinations and counts were carried out in samples taken from the atmosphere in the chamber with a cascade impactor.
The group of the five male and female was exposed to a dispersion of Kalkstickstoff in air at a maximum attainable concentration of 155 mg/m3. Particle size determination and particle counts in air revealed a 99 % particle size range of 0.8 - 3.3 µm. - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- no further details given
- Statistics:
- not reported
Results and discussion
- Preliminary study:
- no preliminary study
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 155 mg/m³ air (analytical)
- Exp. duration:
- 4 h
- Mortality:
- no mortality
- Clinical signs:
- other: During the first 45 minutes of the exposure period the rats were quiet and their behaviour was normal. During the next two hours the rats were slightly restless, but these signs of irritation gradually disappeared. The last hour of the exposure period all
- Body weight:
- not reported
- Gross pathology:
- not reported
- Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- It was concluded that the 4-hour LC50 of Kalkstickstoff was higher than 155 mg/m3 of air.
- Executive summary:
The group of the five male and female was exposed to a dispersion of Kalkstickstoff in air at a maximum attainable concentration of 155 mg/m3. Particle size determination and particle counts in air revealed a 99 % particle size range of 0.8 - 3.3 µm.
During the first 45 minutes of the exposure period the rats were quiet and their behaviour was normal. During the next two hours the rats were slightly restless, but these signs of irritation gradually disappeared. The last hour of the exposure period all rats were completely quiet and seemed to be asleep. No mortality and no signs of intoxication were observed.
The results of the present acute inhalation toxicity study lead to the conclusion that the 4 -hour LC50 of Kalkstickstoff is higher than 155 mg/m3 of air.
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