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Diss Factsheets
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EC number: 801-829-8 | CAS number: 1247790-47-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Experimental result for an structural analogue. Peer-reviewed data, it is assumed that variety of data sources have been consulted, that the test methodology and identity of the test substance has been evaluated, and that a reliable and representative value for the endpoint has been selected.
Data source
Reference
- Reference Type:
- publication
- Title:
- A safety assessment of branched chain saturated alcohols when used as fragrance ingredients
- Author:
- D. Belsito, D. Bickers, M. Bruze, P. Calow, H. Greim, J.M. Hanifin, A.E. Rogers, J.H. Saurat, I.G. Sipes, H. Tagami, The RIFM Expert Panel
- Year:
- 2 010
- Bibliographic source:
- Food and chemical Toxicology 48 (2010) S1-S129
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other: not detailed
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- 2,6-dimethylheptan-4-ol
- EC Number:
- 203-619-6
- EC Name:
- 2,6-dimethylheptan-4-ol
- Cas Number:
- 108-82-7
- IUPAC Name:
- 2,6-dimethylheptan-4-ol
- Details on test material:
- - Name of test material (as cited in study report): 2,6-Dimethyl-4-heptanol
- Molecular formula (if other than submission substance): C9H20O
- Molecular weight (if other than submission substance): 144.25 g/mol
- Structural formula attached as image file (if other than submission substance): see Fig. 1
- Substance type: secondary alcohol
- Log Kow (calculated; EPA, 2010): 3.08.
- Boiling point (calculated; EPA, 2010): 177.59 C.
- Henry’s law (calculated; EPA, 2010): 0.0000412 atm m3/mol
- Vapor pressure: (calculated; EPA, 2010): 0.334 mm Hg; 44.5 Pa (25 C).
- Water solubility (calculated; EPA, 2010): 613.8 mg/l @ 25 C.
- UV spectra available, does not absorb UV light.
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Details on oral exposure:
- single dose
- Doses:
- 4 doses: 1000, 2000, 4000 and 8000 mg / Kg of bodyweight
- No. of animals per sex per dose:
- 5 males per dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 560 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 430 - <= 8 860
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- This substance is regarded as not classified for acute oral toxicity according to REGULATION (EC) No 1272/2008 (CLP) as LD50 > 2.000 mg/Kg of bodyweight.
- Executive summary:
- Five rats per dose were given a single dose
of 2,6-dimethyl-4 -heptanol
at 1000, 2000, 4000, and 8000 mg/kg bodyweight. Observations for mortality
and or systemic effects were made for 14 days. The acute oral LD50 in rats
was calculated to be 3560 mg/kg of bodyweight, with a 95% confidence
interval of 1430 – 8860 mg/kg of bodyweight).
Reference cited: Smyth, H.F., Carpenter, C.P., Weil, C.S., 1949. Range-finding toxicity data, list III. The Journal of Industrial Hygiene and Toxicolology 31 (1), 60–62.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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