Registration Dossier
Registration Dossier
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EC number: 217-775-8 | CAS number: 1951-97-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In humans, majority of the absorbed piperazine was excreted through the urinary route and a minor fraction through the feaces. There is a wide variation in the rate at which piperazine is excreted by different individuals. Also, there was no significant difference between the rates of excretion of piperazine citrate, adipate, and phosphate.
In the study conducted with pigs,a similar behaviour was noted with most of the piperazine being excreted out of the living system through the urinary route. One metabolite N-mononitrosopiperazine was identiofied in this study.
Thus, from the human and animal toxico-kinetic study, it can be assumed that the chemical piperazine, compound with phosphoric acid shall have low bio-accumulation potential within the living system.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
In humans, majority of the absorbed piperazine was excreted through the urinary route and a minor fraction through the feaces. There is a wide variation in the rate at which piperazine is excreted by different individuals. Also, there was no significant difference between the rates of excretion of piperazine citrate, adipate, and phosphate. In the study conducted with pigs,a similar behaviour was noted with most of the piperazine being excreted out of the living system through the urinary route. One metabolite N-mononitrosopiperazine was identiofied in this study.
Thus, from the human and animal toxico-kinetic study, it can be assumed that the chemical piperazine, compound with phosphoric acid shall have no bio-accumulation potential within the living system.
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