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EC number: 500-038-2 | CAS number: 25322-68-3 1 - 4.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed publication
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The Subchronic Inhalation Toxicity Of Polyethylene Glycol 200 In the Rats
- Author:
- J. W. Crook S. A. Thomson, J. To Weimer P. D. Hott R. L. Farrand, PhD A. Eo Cooper C. Lilly E. G. Cumminqs, D. H. Heitkamp
- Year:
- 1 980
- Bibliographic source:
- Army Armament Research And Development Command Aberdeen Proving Ground Md Chemical Systems Lab
- Reference Type:
- publication
- Title:
- Repeated dose inhalation toxicity study of the test chemical
- Author:
- Crook et al
- Year:
- 1 980
- Bibliographic source:
- Army Armament Research And Development Command Aberdeen Proving Ground Md Chemical Systems Lab
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Subchronic Inhalation Toxicity Of Polyethylene Glycol 200 In the Rats
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylated
- EC Number:
- 500-038-2
- EC Name:
- Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylated
- Cas Number:
- 25322-68-3
- Molecular formula:
- (C2-H4-O)mult-H2-O
- IUPAC Name:
- Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylated
- Details on test material:
- - Name of test material (as cited in study report): Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylated
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Source:Charles River Breeding Laboratories
- Weight at study initiation:115 gm and females approximately 77 gm
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus:dynamic ~irflow chambers
- Method of holding animals in test chamber:
- Method of conditioning air:air conditioner
- System of generating particulates/aerosols:
- Temperature, humidity, pressure in air chamber:maintained at a constant level. - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- 6 hours a day, 5 days a week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100,1000 mg/m3
Basis:
nominal conc.
- No. of animals per sex per dose:
- 216 rats
- Control animals:
- yes, sham-exposed
- Details on study design:
- No data
- Positive control:
- No data
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data
- Time schedule:
- Cage side observations checked in table [No.?] were included.
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule:
BODY WEIGHT: Yes
The .animals used in the PEG 200 study were .weighed individually at approximately 2-week intervals. The average weights for the various groups, i.e., males and females for the controls, low- and high-dose levels, were recorded.
FOOD CONSUMPTION:
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: Yes / No / No data
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: Yes
WATER CONSUMPTION: No data
- Time schedule for examinations:
OPHTHALMOSCOPIC EXAMINATION: No data
- Time schedule for examinations:
- Dose groups that were examined:
HAEMATOLOGY: Yes
- Time schedule for collection of blood:
- Anaesthetic used for blood collection: Yes (identity) / No / No data
- Animals fasted: Yes / No / No data
- How many animals:
- Parameters checked in table [No.?] were examined.
CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood:
- Animals fasted: Yes
- How many animals:
- Parameters checked in table [No.?] were examined.
URINALYSIS: No data
- Time schedule for collection of urine:
- Metabolism cages used for collection of urine: Yes / No / No data
- Animals fasted: Yes / No / No data
- Parameters checked in table [No.?] were examined.
NEUROBEHAVIOURAL EXAMINATION: No data
- Time schedule for examinations:
- Dose groups that were examined:
- Battery of functions tested: sensory activity / grip strength / motor activity / other:
OTHER: - Sacrifice and pathology:
- GROSS PATHOLOGY: Groups of male and female rats were euthanatized following 6 and 13 weeks of exposure to PEG 200 aerosol. Another group of rats and mice was euthanat ized 30 days after exposure to PEG 200. At termination and necropsy, tissues were evaluated grossly and preserved in 10% buffered formalin. The tissues were imbedded in paraffin and subsequently processed for staining with hematoxyl in and eosin. Tissues from the following were evaluated microscopically.
HISTOPATHOLOGY: Yes (see table) / No / No data - Other examinations:
- Organ Weight:brain, eye, adrenal, thyroid, trachea, lung, turbinates, kidney, 1 iver, spleen, heart, esophagus, stomach, small intestine, large intestine, pancreas, urinary bladder, testes, ovaries, and uterus. Before fixing the hearts, lungs, livers, kidneys, and gonads, they were weighed, and organ-to-body-weight ratios were calculated.
- Statistics:
- The data were compared statistically using an analysis of variance (ANOVA) which distinguished differences according to sex, exposure level, and the effect of dose within sexes
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Details on results:
- -Toxic Signs. No obvious pattern of overt toxic signs was seen in the rat s or mi ce exposed to either 100 or 1000 mg/m3 of PEG 200. After each exposure, the fur of the animals exposed to the high dose appeared oi I y.
- MortaIity. None of the test rats died dur i ng the 13-week exposure or the 3D-day postexposure observation.
-Hematology and blood chemistry.
Hematology. During the 13-week exposure or the 3D-day postexposure period there were no consistently significant changes in red blood cell count, total and differential white blood cell count, hematocrit, or hemoglobin in the rats .
-Blood chemistry:There were no consistently 'significant changes in rat blood chemistry at the end of the 6- or 13-week exposures or the 30-day postexposure period.
-In male rats exposed for 13-weeks to the high dose, there appeared to be a slight decrease in the P-R interval in the EKG compared to the control animals. The usual abnormal ity associ ated with the P-P interval is an increase in duration, which indicates a slowing of the atrial conduction system. This interval will vary inversely with heart rate, but heart rate did not appear to he a factor in the present study. In any event, the decrease was not associated with any abnormality and may be considered inconsequential.
-PEG 20:did not product any adverse physiological effects on the rats exposed to the IOn and lnnn mg/m 3 concentrations for the various exposure periods
-Fischer 344 exposed rats, both males and females, showed no definite pattern as to weight loss or gain. At the end of the postexposure period the rats weighed as much as, or slightly greate than, the controls.
-Mild to moderate proliferative interstitial pneumonia was seen in nine rats, (three control males, five exposed males (two low- and three high-dose), and one female - low-dose. Acute to subacute i nf I ammat i on of the turb i nates was observed in one control female and two exposed (low-dose) males.
-Infiltration of foamy macrophages occurred in the lungs of one exposed (high-dose) male. Suppurative inflammation of the turbinates was seen in a contro I fema I e. A rena I cort i ca I cyst was found. in one control female no spontaneous deaths occurred
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 1 000 mg/m³ air
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: no adverse toxicological, physiological, hematological, blood chemical, and pathological effects were observed.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The no observed adverse effect concentration (NOAEC) value of the test chemimcal in rats was observed at dose level of 1000 mg/m3.
- Executive summary:
Rats were exposed to airborne concentrations of 100 mg/m3 and 1000 mg/m3 of test chemical for periods up to 13 weeks. Toxicological, physiological, hematological, blood chemical, and pathological effects were evaluated during the course of the exposures. No significant lesions observed in this study occurred exclusively in exposed animals and the severity of lesions which were found was not dose-related. The test chemical did not induced lesions in rat tissue at the dosage level and exposure/post exposure periods evaluated in this study. Organ:body weight ratios in rats at all concentrtions and for the 6- and 13-week exposure periods and the 30-day postexposure period showed no pattern of significance that could be related to test chemical. The mice organ:body weights for the 6-week·exposure period are unavailable. No pattern of significance could be related to test chemical exposure for the 13-week or the 30-day postexposure periods. The test chemical did not product any adverse physiological effects on the rats exposed to the 100 and 1000 mg/m 3 concentrations for the various exposure peri ods. This was not unexpected because the test chemical appear to present. There were no consistently 'significant changes in rat blood chemistry at the end of the 6- or 13-week exposures or the 30-day postexposure period. It appears that the test chemical produced no positive effects in the rodents at the 100 and 1000 mg/m3 test chemical concentrations over the 13 weeks of exposure used in this study. Thus it is concluded that the no observed adverse effect concentration (NOAEC) of the test chemical in rats was observed at dose level of 1000 mg/m3.
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