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Diss Factsheets
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EC number: 935-756-9 | CAS number: 1344-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1991
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Study is not performed according to an OECD Guideline, no GLP, and the documentation is not sufficient for assessment and not convincing for an expert judgment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Cell Toxicity, Hemolytic Action and Clastogenic Activity of Asbestos and its Substitute
- Author:
- Kimiko Koshi, Norihiko Kohyama, Toshihiko Myojo and Kazuo Fukuda
- Year:
- 1 991
- Bibliographic source:
- Industrial Health, 1991, 29, pp 37-56
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Executive summary:
In vitro biological effects of xonotlite fibers were assessed, such as the cell toxicity in Chinese hamster lung (CHL) cells, and the hemolysis of human erythrocytes. Xonotlite had a fibrous form about 5 um in length and less than 0.1 um in diameter. Survival of CHL cells in the absence or presence of xonotlite fibers was determined by colony-forming efficiency after 7 days from a single-cell suspension. The hemolytic activity of xonotlite fibers was calculated from the average optical density of three replicates and was expressed as a percentage of the optical density of the totally lysed control (100%). For cytotoxicity the toxic doses (TD50: the amounts of fibers necessary to inhibit the colony-forming efficiency of CHL cells by 50%) of fibers was determined. The TD50 of fibrous xonotlite was more than 50 ug/ml. For hemolysis the hemolytic doses (HD50: dust dose necessary to cause 50% hemolysis of human erythrocytes) of fibrous xonotlite was determined. To achieve 50% hemolysis, 380 ug/ml of xonotlite was required.
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