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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 204-557-2 | CAS number: 122-60-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Glycidyl ethers
- Author:
- Lane JM
- Year:
- 1 980
- Bibliographic source:
- Vert Hum Toxicol 22, 99-101
- Reference Type:
- secondary source
- Title:
- Toxicological Evaluations 3 - Potential health hazards of existing chemicals
- Author:
- BG Chemie
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- Deviations:
- yes
- Remarks:
- limited documentation
Test material
- Reference substance name:
- phenyl glycidyl ether
- IUPAC Name:
- phenyl glycidyl ether
- Details on test material:
- - Name of test material (as cited in study report): phenyl glycidyl ether
No further information.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data.
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remarks on MMAD:
- MMAD / GSD: No data.
- Details on inhalation exposure:
- No data.
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- No data.
- Duration of treatment / exposure:
- 6 hours/day on 19 consecutive days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1.75, 5.84, 11.2 ppm (corresponding to ca. 0.01, 0.036, 0.07 mg/l (calculated by Derelanko M, 2008)
Basis:
analytical conc.
- No. of animals per sex per dose:
- 8
- Control animals:
- not specified
- Details on study design:
- No data.
- Positive control:
- No data.
Examinations
- Observations and examinations performed and frequency:
- No data.
- Sacrifice and pathology:
- No data.
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- focal degenerative changes involving the seminiferous tubules in both gonads in one animal of the 1.75 dose group, in 1 animal of the 5.84 ppm dose group and in 3 animals of the 11.2 ppm dose group.
Effect levels
- Dose descriptor:
- LOAEC
- Effect level:
- ca. 0.01 mg/L air (analytical)
- Based on:
- test mat.
- Remarks:
- corresponding to 1.75 ppm
- Sex:
- not specified
- Basis for effect level:
- other: focal degenerative changes involving the seminiferous tubules in both gonads in one animal of this dose group, in 1 animal of the 5.84 ppm dose group and in 3 animals of the 11.2 ppm dose group.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.