Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 941-924-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There is no toxicokinetics information available on the target substance. There are 3 studies available on similar structures, which indicate that the bioaccumulation potential is likely to be low.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Read-across justification
From medium-long fatty chain triglycerides
·Carbon number in Fatty Acids: C6 -18
·Carbon number in Polyol: C3
·Total Carbons in Polyol Ester: C21 - C57
·Molecular Weight: 386 - 890
To Fatty Acids, C5 -9
·Carbon number in Fatty Acids: C5-9
·Carbon number in Polyol: C6
·Total Carbons in Polyol Ester: C26 - C32
·Molecular Weight: 400 - 540
All of them are triesters formed by the esterification of a triol (glycerin in the source substances and trimethylolpropane in the target one).
For all of them, it is valid to assume that, when metabolism of these triesters takes place, this firstly leads to the generation of the corresponding fatty acids and of the polyol alcohol.
For the source substances this relates to glycerin and three C6 -18 fatty chain acid units.
For the target substance “TMP Fatty Acids, C5 -9” this relates to trimethylolpropane and three C5-9 fatty chain acid units.It is not expected significative different behaviour in terms of enzymatic lipolysis by gastric and duodenal juice among the source substances and the target one in consideration of the similar lenght chain and structure distribution of the involved fatty acids and of the similar structure of the two involved polyols, both non toxic molecules and not classified according to the 1272/2008 EC.
The target substance (similarly to the source substances) has an estimated water solubility of < 5.289 x 10-5mg/L at 25 ° C and a predicted log Kow value > 8.7. The oral absorption of highly lipophilic substances (log Kow ≥ 4) may be limited by the inability of such substances to dissolve in gastrointestinal fluids and therefore make contact with the mucosal surface. However, the absorption of such substances will be increased if they undergo micellular solubilisation by bile salts. In consideration of the similar properties in these terms between the hydrolized products of the source and the target substances, no significative differences in terms of absorption rate and behaviour are expected.
With regards to the dermal absorption, at log Kow values above 6, the rate of transfer between the stratum corneum and the epidermis will be slow and will limit absorption across the skin and uptake into the stratum corneum itself may be slow. Maximum dermal absorption is often associated with values of log Kow between +1 and +2 ( ECETOC (European Centre for Ecotoxicology and Toxicology of Chemicals). Monograph No, 20; Percutaneous absorption. August 1993 ). In addition, the substance must be sufficiently soluble in water to partition from the stratum corneum into the epidermis. The target substance, similarly the source substances, has an estimated water solubility < 5.289 x 10-5 mg/L at 25 ° C therefore dermal uptake is likely to be low.
About the inhalation absorption, the target substance, as the source subtances, has a low vapour pressure, therefore a significant inhalation exposure to vapours is not expected. Moderate log Kow values (between -1 and 4) are favourable for absorption directly across the respiratory tract epithelium by passive diffusion. The target substance, as the sources substances, has a high log Kow value (> 8.7) therefore it may be taken up by micellular solubilisation particularly as the target substance, as the source substances, is poorly soluble in water (< 5.289 x 10-5mg/L at 25 ° C)
The read-across is, then, considered justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.