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Diss Factsheets
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EC number: 941-220-5 | CAS number: 1126076-86-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study with up-to-date OECD method on the registration substance with a high purity
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction mass of 2,9-dimethoxy-5,12-dihydroquino[2,3-b]acridine-7,14-dione and 2,9-dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dione
- EC Number:
- 941-220-5
- Cas Number:
- 1126076-86-5
- Molecular formula:
- PV54: C22H16N2O4 PR202: C20H10Cl2N2O2
- IUPAC Name:
- Reaction mass of 2,9-dimethoxy-5,12-dihydroquino[2,3-b]acridine-7,14-dione and 2,9-dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dione
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals / tissue source
- Species:
- other: bovine eyes
Test system
- Vehicle:
- physiological saline
- Controls:
- yes
- Duration of treatment / exposure:
- 4 hours
- Number of animals or in vitro replicates:
- 3 eyes per group
Results and discussion
In vivo
Results
- Irritation parameter:
- other: In vitro Irritancy scores
- Basis:
- mean
- Time point:
- other: 4 hours
- Score:
- -0.4
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- C. I. Pigment Violet 55 did not induce ocular irritation through both endpoints, resulting in a mean in vitro irritancy score of -0.4 after 240 minutes of treatment.
Finally, it is concluded that this test is valid and that C. I. Pigment Violet 55 is not irritant in the Bovine Corneal Opacity and Permeability test under the experimental conditions described in this report.
Since C. I. Pigment Violet 55 induced an IVIS ≤ 3, no classification is required for eye irritation or serious eye damage. - Executive summary:
C. I. Pigment Violet 55 was tested in a 20% (w/w) suspension. The individual in vitro irritancy scores for the negative controls ranged from -1.8 to 1.5. The individual positive control in vitro irritancy scores ranged from 137 to 153 (APPENDIX 2, Table 5). The corneas treated with the positive control were turbid after the 240 minutes of treatment.
The corneas treated with C. I. Pigment Violet 55 showed opacity values ranging from -3 to 0 and permeability values ranging from 0.018 to 0.092. The corneas were clear after the 240 minutes of treatment with C. I. Pigment Violet 55. No pH effect of the test substance was observed on the rinsing medium. Hence, the in vitro irritancy scores ranged from -2.4 to 1.7 after 240 minutes of treatment with C. I. Pigment Violet 55.
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