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Diss Factsheets
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EC number: 230-745-9 | CAS number: 7300-34-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- BASF test: Animals were exposed for 1, 5 and 15 min and 20 h, respectively; occlusive dressing was used; animals were observed for only 8 days
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,3'-[butane-1,4-diylbis(oxy)]bispropanamine
- EC Number:
- 230-745-9
- EC Name:
- 3,3'-[butane-1,4-diylbis(oxy)]bispropanamine
- Cas Number:
- 7300-34-7
- Molecular formula:
- C10H24N2O2
- IUPAC Name:
- 3-[4-(3-aminopropoxy)butoxy]propan-1-amine
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Butandiol-di(aminopropyl)-ether
- Physical state: liquid
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- An application site of 2.5 cm x 2.5 cm was covered with the liquid test substance
- Duration of treatment / exposure:
- 1, 5, 15 min and 20 h
- Observation period:
- 8 days
- Number of animals:
- 2 per time point
- Details on study design:
- After application time, the skin was washed with water
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 min exposure - next day-observation
- Reversibility:
- not fully reversible within: 8 days (one animal)
- Remarks on result:
- other: Slight erythema were observed on next day.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 5 min exposure - 24 h post exposure
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: Moderate to strong erythema was observed one hour following treatment; soft, red-brownish necrosis was visible 24 h after exposure; hard, leather-like necrosis was observed 8 days later.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 5 min exposure - 24 h post exposure
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: Slight erythema and edema.
- Irritation parameter:
- other: necrosis
- Basis:
- mean
- Time point:
- other: 15 min exposure - 24 h post-exposure
- Reversibility:
- not reversible
- Remarks on result:
- other: Lesions were not reversible until the end of the observation period (day 8), when leather-like necrosis was present in both animals.
- Irritation parameter:
- other: necrosis
- Basis:
- mean
- Time point:
- other: 20 h exposure - 24 h post exposure
- Reversibility:
- not reversible
- Remarks on result:
- other: Lesions were not reversible and the formation of transverse folds was additionally visible 8 days after substance application.
- Irritant / corrosive response data:
- 1 min exposure: slight erythema in both animals the next day; no abnormalities were detected in one animal 8 days after substance application, whereas strong scale formation was present in the other rabbit at day 8 post-exposure.
5 min exposure: moderate to strong erythema was observed in one rabbit one hour following treatment; soft, red-brownish necrosis was visible 24 h post-exposure; hard, leather-like necrosis was observed in this animal 8 days later; the other rabbit showed slight erythema and edema 24 h post-exposure; 8 days later, slight erythema was still visible and strong scale formation was present
15 min exposure: strong, leather-like, hard necrosis in one animal and soft, anemic, parchmenty necrosis in the second rabbit 24 h following substance application; these lesions were not reversible until the end of the observation period (day 8), when leather-like necrosis was present in both animals
20 h exposure: hard, leather-like, overall necrosis in both animals 24 h following substance application; lesions were not reversible and the formation of transverse folds was additionally visible 8 days after substance application.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
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