Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-254-0 | CAS number: 3047-32-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Does not meet important criteria of test guideline (e.g. confirmatory analysis of test solutions not reported). Even though there are deficiencies within the study, nominal test concentration greatly exceeded the maximum guideline test concentration required (100 mg/L), as a result it can be concluded that the test substance is not toxic to Daphnia.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Not reported. Samples of the stock solution and the highest tested concentration at 0 h and 48 h were collected and stored in the freezer until analysed by the sponsor. No results have been presented to confirm concentrations were achieved.
- Vehicle:
- no
- Details on test solutions:
- 10 001,1 mg of the test item was added to 1000 mL reconstituted test water (dilution water) and stirred on the day of the test start. Since floccule was observed, the solution was membrane filtered. The filtrate was used as stock solution (approx. 10000 mg/L). The test solutions were made by dilution of the stock solution with reconstituted test water.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The test used newly hatched animals, 6 to 24 hours old, that were incubated for 48 hours in a gradient of the test item. The animals were taken from Toxicon's continuous culture of Daphnia magna.
The culture originates from DHI, Denmark, and is on working days fed with approximately 50-75 mL green algae Pseudokirchneriella subcapitata. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not applicable
- Hardness:
- 250±25 mg/L (expressed as CaC03).
- Test temperature:
- 21±1° C
- pH:
- 7.99 to 8.09
- Dissolved oxygen:
- 95.9 to 101.6%
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal concentrations: Control, 2000; 4000; 6000; 8000 and 10000 mg/L.
- Details on test conditions:
- Reconstituted test water, as specified in OECD TG no. 202, was used as dilution water (specified below). In the controls, only reconstituted test water was used. The animals were incubated in glass Petri dishes (50 mL), with 25 mL solution. Four replicates, with five animals in each replicate, were used for both the test concentrations and for the control. The dishes were incubated in a thermo constant room at a temperature of 21±1° C and subdued light with the light period of 16 hours light: 8 hours darkness. Before the experiment start, pH and oxygen saturation was measured in all the solutions. The numbers of immobilised animals were observed at 24 and 48 hours in all the test dishes. At the end of the experiment pH and oxygen saturation were measured in all the test groups (4 pooled replicates/group).
- Reference substance (positive control):
- yes
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 6 910 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 4 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- A qualification test on the Daphnia magna culture was made on the 15th of May 2008 to assure the quality of the test animals. EC50 was 1,3 mg/1, which confirmed that the culture was suitable as a test organism according to OECD TG no. 202
- Reported statistics and error estimates:
- An EC50-value of 6910 mg/L was determined (by graphic interpolation) for the 48 hours of exposure for the test item TMPO
- Conclusions:
- An EC50-value of 6910 mg/L was determined (by graphic interpolation) for the 48 hours of exposure for the test item TMPO
The NOEC was 4000 mg/L - Executive summary:
Due to the lack of analytical chemistry the data is insufficient for convincing expert judgment to conclude that test conditions were maintained satisfacatorily. Even though there are deficiencies within the study, nominal test concentration greatly exceeded the maximum guideline test concentration required (100 mg/L), as a result it can be concluded that the test substance is not toxic to Daphnia and therefore it is considered that conclusions can be drawn from the report.
Reference
Description of key information
The 48-hour EC50 was found to be 6910 mg/l, thereby exceeding the normal highest dose recommended for such studies (1000 mg/L). Therefore, in the chemical safety assessment performed according to Article 14(3) in connection with Annex I section 3 (Environmental Hazard Assessment) no hazard was identified, therefore no PNEC can be derived.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 6 910 mg/L
Additional information
A 48 -hour acute Daphnia magna toxicity test was carried out for 3-ethyloxetane-3-methanol according to OECD guideline 202. The 48-hour EC50 was 6910 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.