Registration Dossier
Registration Dossier
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EC number: 267-021-7 | CAS number: 67762-52-1
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to investigate further the long-term toxicity to fish. Thus, in accordance to Annex IX, column 2 no further long-term toxicity test to fish is proposed.
According to the “Guidance on information requirements and chemical safety assessment Chapter R.7b: Endpoint specific guidance, R.7.8.5.3” (ECHA, 2014), long-term testing of fish should only be conducted if it represents the most sensitive taxonomic group. The Guidance states that if invertebrates are likely to be more sensitive than fish and algae or the relative sensitivity of invertebrates cannot be predicted, long-term testing on Daphnia sp. should be preferred instead of fish. Since no effects were observed in the acute aquatic studies with carboxylic acids, C5-9, hexaesters with dipentaerythritol (CAS 67762-52 -1) or read-across substances, fish cannot be identified as the most sensitive organism, and consequently long-term testing of Daphnia magna was preferred, as recommended by the Guidance document. The long-term toxicity study determined no detrimental effects of the substance on Daphnia magna. The recorded NOEC ≥100 mg/L (nominal) based on the reproduction rate.
Chronic effects of the substance on aquatic organisms are not expected.
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