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Diss Factsheets
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EC number: 233-153-9 | CAS number: 10045-95-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 11 March 1980 - 14 March 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Non-GLP study performed with a mixture of lanthanum trinitrate (75%) and neodymium trinitrate (25%), containing the following relevant methodological deficiencies: limited information on test conditions and test animals, no scoring at 1 and 48h, no 14 day observation period, occlusive wrap instead of semi-occlusive wrap used, 24h of exposure instead of 4 hours, conclusion was based on the observations made on intact skin but also abraded skin.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- no scoring at 1 and 48 hours; 24 hours of exposure instead of 4 hours; occlusive wrap instead of semi-occlusive; also abraded skin exposed; no 14 day observation period
- GLP compliance:
- no
Test material
- Reference substance name:
- Mixture of 75% lanthanum nitrate and 25% neodymium nitrate
- IUPAC Name:
- Mixture of 75% lanthanum nitrate and 25% neodymium nitrate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved; then intact or abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 25 hours and 72 hours after application of the test substance
- Number of animals:
- 4
- Details on study design:
- TEST SITE
- Area of exposure: trunk of the animals
- % coverage: no percentage specified, however small disks were applied of 3 cm diameter (aluminium disks covered with gauze)
- Type of wrap if used: adhesive bandage covering the trunk of the animal
REMOVAL OF TEST SUBSTANCE
- The discs were removed after 24 hours of exposure
SCORING SYSTEM:
Oedema and erythema were scored. The study protocol was based on the Draize or patch-test technique.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 25hr and 72 hr
- Score:
- 1.31
- Max. score:
- 12
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: mean calculated on observations of abraded and intact skin zones
- Irritant / corrosive response data:
- Erythema scoring of abraded zones: the skin was grey at the abraded place
Erythema scores at 25h (intact skin): 0, 0, 0, 2 (respectively)
Erythema scores at 72h (intact skin): 0, 0, 0, 2 (respectively)
Edema scores at 25h (intact skin): 0, 0, 0, 1 (respectively)
Edema scores at 72h (intact skin): 0, 0, 0, 0 (respectively)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the scoring system used (mean value of the observations in intact skin as well as abraded skin), the product existing of 75% lanthanum nitrate and 25% neodymium nitrate is classified as a mild primary skin irritant when applied as received. Based on the criteria of the CLP Regulation, the mixture would not be classified as a skin irritant, assuming that the effects are reversible within 14 days and are not increased after 72h.
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