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EC number: 256-289-0 | CAS number: 46948-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-12-07 - 1984-12-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented, guideline conform GLP study, which meets basic scientific principles
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund
- Weight at study initiation:
male: mean 200.1 g
female: mean 184.6 g
- Labelling: coat labelling with KMnO4
- Housing: 5 per cage; air-conditioned
- withdraw of feed: approx. 16 hours before application; 3 - 4 hours after application
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3 °C
- Humidity (%): 50 +/- 20 %
- Photoperiod (hrs dark / hrs light): 12 hours periodically - Route of administration:
- oral: gavage
- Vehicle:
- other: 1,2 propyleneglycol/water
- Doses:
- 1250/ 2000/ 2500/ 3150/ 4000/ 5000 mg/kg
- No. of animals per sex per dose:
- Dose number of animals
in mg/kg Kgw. male female
1250 - 5
2000 - 5
2500 - 5
3150 5 5
4000 5 -
5000 5 5 - Control animals:
- no
- Details on study design:
- The test item was presolved in 12 mL 1,2-Propylenglycol and emulified in 38 mL de-ionized water. The conditioned test item was applicated via gavage. After the application was performed the following parameters were recorded: process of intoxication, rate of lethalityand elapsed time of lethality. Post-observation was carried out for 14 days. Every week the testing animals were weighed. Lethal intoxicated animals were dissected and macroscopic findings were recorded. Those testing animals surviving the post-observation were put to death by CO2. These animals were also dissected and macroscopic findings were recorded.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 540 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 040 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Results given in Table 1: Mortality incidence
- Clinical signs:
- other: Unspecific clinical signs only on the treatment day such as piloerection, ruffled fur, depressed activity, increased respriration etc.
- Gross pathology:
- Observations in dead males and females: stomach filled with the test substance, intestine filled with clear liquid, damage on the gastro-intestine tissues, bladder filled with liquids, lung filled with bloody liquids.
Observation in dead females only: dark adrenals, pale coloured liver - Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The registration substance was investigated for its acute oral toxicity in rats according to the OECD Guideline 401. The LD50 was determined as 4540 mg/kg bw for males and 3040 mg/kg bw for females. No classification is warranted according to 67/548/EEC (DSD) and Acute Tox. 5 is warranted according to GHS.
- Executive summary:
The registration substance was investigated for its acute oral toxicity in rats according to the OECD Guideline 401. The LD50 was determined as 4540 mg/kg bw for males and 3040 mg/kg bw for females. No classification is warranted according to 67/548/EEC (DSD) and Acute Tox. 5 is warranted according to GHS.
Reference
Table 1: Mortality incidence
Dose | Mortality | |||
mg/kg bw | male | female | ||
absolute | relative [%] | absolute | relative [%] | |
1250 | 0/5 | 0 | ||
2000 | 0/5 | 0 | ||
2500 | 1/5 | 20 | ||
3150 | 1/5 | 20 | 3/5 | 60 |
4000 | 1/5 | 20 | ||
5000 | 3/5 | 60 | 5/5 | 100 |
LD50 | 4540 mg/kg bw | 3040 mg/kg bw | ||
CL (p = 0.05) | 3600 - 6660 mg/kg bw | 2410 - 4390 mg/kg bw |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Justification for classification or non-classification
The registration substance was investigated for its acute oral toxicity in rats according to the OECD Guideline 401. The LD50 was determined as 4540 mg/kg bw for males and 3040 mg/kg bw for females. No classification is warranted according to 67/548/EEC (DSD) and Acute Tox. 5 is warranted according to GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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