Registration Dossier
Registration Dossier
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EC number: 226-956-0 | CAS number: 5578-42-7
Endpoint summary
Administrative data
Description of key information
There are no data for skin and eye irritation/corrosion for dichloro(cyclohexyl)methylsilane. However, based on the fact that this substance is a chlorosilane generating hydrogen chloride in the presence of moisture, it is expected to be corrosive. Therefore, in accordance with Column 2 of REACH Annexes VII and VIII, the in vitro and in vivo skin irritation study and eye irritation study (required in Section 8.1.1 and 8.2.1) do not need to be conducted as the available information indicates that the substance meets the criteria for classification as corrosive to skin.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Dichloro(cyclohexyl)methylsilane hydrolyses rapidly in contact with water and moist air, releasing two moles of hydrogen chloride (HCl) for each mole of parent material. Although no reliable in vitro irritation/corrosion studies are available, severe skin, eye and respiratory damage can be expected due to release of HCl. This is consistent with reliable measured data for other chlorosilanes.
Justification for classification or non-classification
Dichloro(cyclohexyl)methylsilane is classified 'Skin Corr. 1A and Eye Dam. 1 with hazard statement H314, 'Causes severe skin burns and eye damage’ according to Regulation (EC) No 1272/2008. There are no specific data for respiratory irritation. However, the additional hazard statement 'EUH071 Corrosive to the respiratory tract' is proposed in accordance with related chlorosilane substances, based on the expected respiratory tract damage caused by the hydrolysis product HCl.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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