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EC number: 263-005-9 | CAS number: 61788-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 17 July, 1990 to 19 July, 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- No analytical measurement was performed.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- as published in 84/449/EEC
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- The test sample was prepared by direct dissolution in water. 1.0 g of the test substance was dissolved in water and the volume adjusted to 1 L. This stock solution was then diluted to give a 0.10 mg/L stock solution from which serial dilutions were made to give the test series.
The test substance was known to absorb to glassware and so saturation of the absorption sites was achieved by soaking the test vessels overnight prior to the start of the test with the test solutions. At 0 h the test vessels were emptied, rinsed with the solution to be tested and then refined with the fresh test solution. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: Laboratory culture originating from a strain supplied by I.R.C.H.A., France.
- Culture: At 21˚C in polypropylene vessels containing 2 L of dechlorinated and aged tap water. Cultures were fed daily with a mixture of fry fish food (liquifry) and a suspension of mixed algae (predominantly Chlorella spp.). Culture conditions ensure that reproduction is by parthenogenesis.
- Selection: Gravid adults were isolated 24 h prior to initiation of the test. Young daphnids produced overnight were used for testing. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No
- Hardness:
- 50 mg/L of CaCO3
- Test temperature:
- 21 ± 1˚C
- pH:
- 7.1-7.2
- Dissolved oxygen:
- 8.3-8.6 mg O2/L
- Nominal and measured concentrations:
- Nominal concentrations: 0.0010, 0.0018, 0.0032, 0.0056, 0.010, 0.018, 0.032, 0.056 and 0.10 mg/L
- Details on test conditions:
- TEST SYSTEM:
- Test water: Dechlorinated (with sodium thiosulphate) and aged laboratory tap water. Total hardness approximately 50 mg/L as CaC03.
- No. of organisms per vessel: 10 per replicate
- No. of vessels per concentration (replicates): Two
EXPOSURE CONDITIONS:
- Test vessels: Glass beakers each containing 200 mL test solution
- Experimental design: 9 test concentrations plus one control, each in duplicate. 20 animals per concentration
- Method of initiation: Daphnia were placed in the test solutions after addition of the test substance
- Loading: 20 mL test solution per organism
- Photo-period: 16h light: 8h dark
- Aeration: None
- Medium renewal: None
CRITERIA OF EFFECT: Daphnia were considered to be immobilised if they were unable to swim for approximately 15 sec after gentle agitation. - Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.016 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other: (95% CL = 0.013-0.021 mg a.i./L)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.009 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other: (95% CL = 0.0072-0.012 mg a.i./L)
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.01 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: (i.e., equivalent to 0.0047 mg a.i./L)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.006 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: (i.e., equivalent to 0.0026 mg a.i./L)
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the 48 h EC50 and NOEC were 0.0091 and 0.0026 mg a.i./L, respectively.
- Executive summary:
A study was conducted to determine the acute toxicity in Daphnia magna exposed to the test substance, C16-18 TMAC (46.5% active), according to the OECD Guideline 202, under static conditions. Daphnia magna (10 per group) were exposed to the test substance at nominal concentrations of 0.0010, 0.0018, 0.0032, 0.0056, 0.010, 0.018, 0.032, 0.056 and 0.10 mg/L for 48 h and immobilisation was determined. The 48 h EC50 and 95% confidence interval were calculated as 0.0091 and 0.0072-0.012 mg a.i./L. The 48 h NOEC was 0.0026 mg a.i./L. No analytical determination of the test substance was performed. Under the test conditions, the 48 hour EC50 and NOEC were 0.0091 and 0.0026 mg a.i./L (nominal), respectively (Handley and Wetton, 1990).
Reference
For result tables and figures, kindly refer to the attached background material section of the IUCLID.
Description of key information
The 48 h EC50 value of the test substance for toxicity aquatic invertebrates, which was determined at 0.0091 mg a.i./L (nominal) has been considered further for hazard/risk assessment.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 9.1 µg/L
Additional information
A study was conducted to determine the acute toxicity in Daphnia magna exposed to the test substance, C16-18 TMAC (46.5% active), according to the OECD Guideline 202, under static conditions. Daphnia magna (10 per group) were exposed to the test substance at nominal concentrations of 0.0010, 0.0018, 0.0032, 0.0056, 0.010, 0.018, 0.032, 0.056 and 0.10 mg/L for 48 h and immobilisation was determined. The 48 h EC50 and 95% confidence interval were calculated as 0.0091 and 0.0072-0.012 mg a.i./L. The 48 h NOEC was 0.0026 mg a.i./L. No analytical determination of the test substance was performed. Under the test conditions, the 48 hour EC50 and NOEC were 0.0091 and 0.0026 mg a.i./L (nominal), respectively (Handley and Wetton, 1990).
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