Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-745-8 | CAS number: 693-21-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
SHORT-TERM TOXICITY TESTING
DEGDN proved to be relatively non-toxic to the freshwater organisms tested.
The invertebrate 48-h LC50s ranged from 90.1 to 355.3 mg/L, with the water flea being most sensitive. All the fish species had similar sensitivities (mean 96-h LC50 = 273.5 mg/L), except for the fathead minnows, which were somewhat more tolerant with an LC50 of 491.4 mg/L.
There was a dose-response relationship between Selenastrum capricornutum growth and increased DEGDN concentration, the lowest concentration of DEGDN tested (58.4 mg/L) caused a significant reduction in algal cell density and chlorophyll a when compared to control values (Student's t tests with Bonferroni's correction for simultaneous comparisons, p = 0.0001). The 5-day minimum algistatic concentration based on cell density was 171.6 mg/L (95% asymmetrical confidence limits = 86.9 - 335.5 mg/L). The minimum algicidal concentration was greater than 542.4 mg/L, the highest concentration tested. When algal cultures from this treatment were restarted in clean media, they resumed logarithmic growth. The 5-day EC50 for DEGDN and this alga was 39.1 mg/L based on dry weight (95% asymmetrical confidence limits = 28.8 - 52.9 mg/L). Thus, Selenastrum capricornutum was the most sensitive species tested with this compound.
The information about toxicity of DEGDN to microorganisms are not available. The result of study “Determination of the Inhibition of the Respiration of Activated sludge when exposed to Ethylene Glycol Dinitrate according to OECD 209” was used for read across.
LONG-TERM TOXICITY TESTING
The following chronic tests were conducted with TNG: 7-d cladoceran, 60-d ELS rainbow trout, and 28-d ELS fathead minnow. Results of these studies were used for read across for DEGDN.
The LOEC and NOEC for the cladoceran during a 7-d survival and reproduction test, were 5.48 and 3.23 mg/L,
respectively, based on a reduction in neonate production. The LOEC and NOEC for rainbow trout during a 60-d ELS test were 0.06 and 0.03 mg/L (based on a reduction in dry weight). A 28-d ELS with fathead minnow produced a LOEC and NOEC of 0.20 and 0.12 mg/L (based on a reduction in hatching success).
The Selenestrum capricornutum test is an indicator of chronic toxicity since it measures reproduction over the exposure period. Thus, although not directly comparable to the acute toxicity data, the algal data give an indication of possible chronic effect levels for DEGDN.
HARMONIZED CLASSIFICATION
DEGDN has classification harmonized in Annex VI of CLP as Aquatic Chronic 3. The criteria for classifying and categorising substances as “hazardous to the aquatic environment” for Category Chronic 3 are:
Substances for which adequate chronic toxicity data are not available:
96 hr LC50 (for fish) > 10 to ≤ 100 mg/l and/or
48 hr EC50 (for crustacea) > 10 to ≤ 100 mg/l and/or
72 or 96 hr ErC50 (for algae or other aquatic plants)> 10 to ≤ 100 mg/l
and the substance is not rapidly degradable and/or the experimentally determined BCF≥ 500 (or, if absent, the log Kow≥ 4).
CONCLUSION ON C&L
Acute effect values for all three trophic levels are available. C&L is based on data from short-term tests for fish, invertebrates and algae.
Based on existing studies DEGDN is inherently biodegradable and algae Selenastrum capricornutum is the most sensitive species tested with this compound – EC50(5d) = 39.1 mg/L.
These results are consistent with harmonized classification Aquatic Chronic 3.
CONCLUSION ON CSA - PNEC DERIVATION
Results of chronic study (60-d ELS test for rainbow trout) for TNG are used for derivation PNEC. Key value for CSA is NOEC = 0.03 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.