Registration Dossier
Registration Dossier
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EC number: 203-533-9 | CAS number: 107-93-7
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- adopted July 17, 1992
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- Non adapted activated suldge from the municipal sewage plant at D-31137 Hildesheim
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 50 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Reference substance:
- benzoic acid, sodium salt
- Remarks:
- 45 mg/L
- Test performance:
- validity criteria were fulfilled
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 10
- Sampling time:
- 1 d
- Remarks on result:
- other: mean degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 60
- Sampling time:
- 8 d
- Remarks on result:
- other: mean degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 99
- Sampling time:
- 28 d
- Remarks on result:
- other: mean degradation
- Results with reference substance:
- In the toxicity control containing both test and reference item 87% degradation occured within 14 days. The functional control reached the pass level > 60% after 2 days and came to 100% after 28 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test item must be regarded as readily biodegradable in the 10-d-window.
Reference
Description of key information
The test item is readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
The ready biodegradability of the test item was assessed according to OECD guideline 301 F ( Dr. U. Noack-Laboratorien, 2007) using activated sludge and a non-adapted method during a 28 day incubation period. The test item reached the 10% level after 1 day and the pass level of 60% after 8 days. The mean biodegradation came to 99% after 28 days. In conclusion, the test item Crotonic acid must be regarded as readily biodegradable in the 10-d-window.
In addition, in a sewage waste water investigation (Hoechst AG, 1979) Crotonic acid showed a degradation of > 65%.
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