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EC number: 242-053-4 | CAS number: 18169-57-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
The key study for repeated dose toxicity is the only reliable study for this endpoint, based on read-across from the related substance triethoxyisobutylsilane (CAS 17980-47-1). The registered substance, trichloroisobutylsilane, and the surrogate substance both hydrolyse in contact with water to produce the common hydrolysis product isobutylsilanetriol, with the other hydrolysis products being hydrogen chloride and ethanol respectively. Although at pH 7, the triethoxy analogue hydrolyses more slowly than the trichloro (half-life 22 hours compared to <1 minute), under acidic conditions such as in the stomach following oral ingestion, the triethoxy substance is expected to hydrolyse rapidly, based on experience with other ethoxy silanes.
Hydrogen chloride, generated by hydrolysis of trichloroisobutylsilane can be expected to cause local irritant or corrosive effects at sufficiently high concentrations. These effects are not addressed by the read-across data.
Short description of key information:
Only one study examining toxicity to reproduction was included in this dataset. This study was a one-generation oral study (OECD 415) in which the read across substance, triethoxyisobutylsilane, was given by gavage at up to 1000 mg/kg bw/day in arachis oil to male and female rats for 10 wk prior to mating and throughout gestation and lactation. The study found no evidence of adverse reproductive effects in the parents or offspring.
Effects on developmental toxicity
Description of key information
The key developmental toxicity study was an oral study in rats conducted according to OECD 414, with gavage administration of up to 1000 mg/kg bw/day of the read across substance, triethoxyisobutylsilane, in arachis oil on gestation days 6-15 and examination at gestation day 20. The study reported slight maternal toxicity but no evidence developmental effects at 1000 mg/kg bw/day. No maternal toxicity was seen at the lower dose of 250 mg/kg bw/day.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
The key study for repeated dose toxicity is the only reliable study for this endpoint, based on read-across from the related substance triethoxyisobutylsilane (CAS 17980 -47 -1). The registered substance, trichloroisobutylsilane, and the surrogate substance both hydrolyse in contact with water to produce the common hydrolysis product isobutylsilanetriol, with the other hydrolysis products being hydrogen chloride and ethanol respectively. Although at pH 7, the triethoxy analogue hydrolyses more slowly than the trichloro (half-life 22 hours compared to <1 minute), under acidic conditions such as in the stomach following oral ingestion, the triethoxy substance is expected to hydrolyse rapidly, based on experience with other ethoxy silanes.
Hydrogen chloride, generated by hydrolysis of trichloroisobutylsilane can be expected to cause local irritant or corrosive effects at sufficiently high concentrations. These effects are not addressed by the read-across data.
Justification for classification or non-classification
The available data do not support classification for reproductive or developmental toxicity under Regulation (EC) No 1272/2008 or Directive 67/548/EEC.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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