Registration Dossier
Registration Dossier
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EC number: 206-564-6 | CAS number: 354-58-5
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited documentation. Read-across
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Principles of method if other than guideline:
- Improved type for a volatile substance
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,1,2-trichlorotrifluoroethane
- EC Number:
- 200-936-1
- EC Name:
- 1,1,2-trichlorotrifluoroethane
- Cas Number:
- 76-13-1
- IUPAC Name:
- 1,1,2-trichloro-1,2,2-trifluoroethane
- Details on test material:
- - Molecular formula: C2Cl3F3 (identical to submission substance)
- Molecular weight: 187.376 g/mol (identical to submission substance)
- Smiles notation: ClC(F)(F)C(Cl)(Cl)F (different from submission substance)
- InChl: InChI=1S/C2Cl3F3/c3-1(4,6)2(5,7)8 (different from submission substance)
- Structural formula: see attachment CAS_76-13-1_Structure.png (under "Illustration (picture/graph)")
- Physical state: liquid
Constituent 1
Study design
- Oxygen conditions:
- not specified
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Duration of test (contact time):
- 4 wk
Initial test substance concentration
- Initial conc.:
- 100 mg/L
Parameter followed for biodegradation estimationopen allclose all
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Parameter followed for biodegradation estimation:
- other: BOD
- Details on study design:
- concentration of test substance: 100 ppm (i.e. 100 mg/L)
concentration of activated sludge: 30 ppm (i.e. 30 mg/L)
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 0
- Sampling time:
- 4 wk
- Parameter:
- other: BOD
- Value:
- 2
- Sampling time:
- 4 wk
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- In an OECD TG 301C test (MITI-I) the test substance 1,1,2-trichloro-1,2,2-trifluoroethane was not readily biodegradable.
The biodegradability of the target chemical 1,1,1-trichloro-2,2,2-trifluoroethane is determined by read-across from an OECD TG 301C test with the source chemical 1,1,2-trichloro-1,2,2-trifluoroethane. The analogue approach is justified in Section 13 (Assessment Reports_Read-Across, in attachment CAS_354-58-5_Read-Across.pdf). As a consequence 1,1,1-trichloro-2,2,2-trifluoroethane is not readily biodegradable. - Executive summary:
In an OECD TG 301C test (MITI-I) the test substance 1,1,2-trichloro-1,2,2-trifluoroethane was not readily biodegradable.
The biodegradability of the target chemical 1,1,1-trichloro-2,2,2-trifluoroethane is determined by read-across from an OECD TG 301C test with the source chemical 1,1,2-trichloro-1,2,2-trifluoroethane. The analogue approach is justified in Section 13 (Assessment Reports_Read-Across, in attachment CAS_354-58-5_Read-Across.pdf). As a consequence 1,1,1-trichloro-2,2,2-trifluoroethane is not readily biodegradable.
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