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EC number: 905-013-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A weight of evidence approach is being conducted, using two studies with read-across substances. The 48 h EC50 to daphnids is 25 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 25 mg/L
Additional information
No short-term toxicity test with aquatic invertebrates with the reaction mass of isomenthone and trans-menthone is available. A weight of evidence approach is being conducted, using two studies with read-across substances DL-Isomenthone (CAS 491-07-6) and L-menthan-3-one (CAS 14073 -97-3), respectively.
The effects of the test item DL-Isomenthone (CAS 491-07-6) to daphnids (Daphnia magna) were investigated according to the EU Method C.2 (1992) under GLP conditions. The 64.5 % DL-Isomenthone is accompanied by 35.2 % of the diastereomeric DL-Menthone (CAS 89-80-5, as well considered isomolar) and is thus comparable with one of the qualities of submission item "reaction mass of isomenthone and trans-menthone 32/65" as given in chapter 1.2. The test organisms were during 48 hours under static conditions in closed vessels exposed to nominal concentrations of 0, 6.5, 13, 25, 50 and 100 mg/L. The dose was verified as Total Organic Carbon (TOC analysis) and found sufficiently constant under the test conditions. As the recovery was below 80 % the effects were assigned to measured concentrations. The 48 h EC50 for daphnids was calculated to be 25 mg/L.
Additional evidence for the validity of this study result is being delivered by the study with L-menthan-3 -one (CAS 14073 -97 -3), where the test item consisted to 84% of L-menthan-3 -one and to 16% of D-isomenthone. This study revealed an EC50 of 30.6 mg/L.
As by the available two studies all four reaction mass components have been tested for acute Daphnia toxicity, the reaction mass therefore can be considered as adequately investigated for this endpoint. The two studies revealed very similar EC values, i.e. 25 mg/L and 30.6 mg/L, respectively. As outcome of the WoE approach, the EC50 value of 25 mg/L as derived by the study with test item consisting of 64.5 % isomenthone and 35.2 % menthone shall be considered as key value for chemical safety assessment.
The following information is taken into account for short-term toxicity to aquatic invertebrates for the derivation of PNEC:
A weight of evidence approach is being conducted, using two studies with read-across substances. The 48 h EC50 to daphnids is 25 mg/L.
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